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Side effects of Letrozole after taking 2yrs

Posted by bizziemom @bizziemom, Mar 11, 2025

I have been on Letazole now for 2yrs following mastectomy. A few months after starting L, I developed atrial flutter. My cardiologist doesnt seem to think its related to any side effects of the L, but, I swear since taking it, my health has diminished over the 2yrs. Has anyone else felt thier health has diminished as well? To include dehydration and just overall feeling 'off' ? My blood presaure has increased some recently and I have not changed my eating habbits either.

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paulsgerl | @paulsgerl | 2 days ago
In reply to @wews "On letrozole for one year now after invasive lobular cancer diagnosis and bilateral mastectomy. Stage 1A..." + (show)
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On letrozole for one year now after invasive lobular cancer diagnosis and bilateral mastectomy. Stage 1A no lymph node involvement and clean margins with no need for chemo since oncotype score was 22. Have stiff joints and hot flashes but I try to exercise a lot including 3 days of weights and yoga and walking and cycling for my knees. I am 71 and hate being on the leteozole. I have atrial tachycardia and get more afib alerts now than before I started taking AI meds. My cardiologist added Lesortan and zetia to ease the burden on my heart and to keep my LDL low. I didn’t tolerate statins. Since I had arythmia issues before my cancer diagnosis I can’t tell if leteozole made them worse. I was told I only have to be on them another four years but there are days were I wonder if the side effects will get worse. My knees are the sorest and stiff. I get so tired and that is new. I am an active person and hate feeling tired from the time I wake up. I guess we have no choice but to stay the course and try to keep moving. I do believe motion is lotion and it helps to move, breathe and stretch and eat healthy. Best of luck to you.

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I’ve been on all three aromatase inhibitors and I’ve now been on letrozole for about five months. I do have hollow, aching pain in my lower back, but I’m not sure if it’s new or if the AI is just making an existing issue worse.
I try to stay very active I get between 10,000 and 17,000 steps most days. I joined the gym at our local hospital, and their hot tub and heated pool have been amazing. I’m planning to start Pilates soon to see what I can and cannot do safely.
My parents are 86 and almost 90, and my sons are 39 and 40 and my grandchildren of 14 and four. I help my parents by living with them and driving and anything else they need. At the same time they are helping me. They’re still pretty self sufficient, which motivates me even more to stay as mobile and strong as possible.

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