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Should one consider repeating a cycle of docetaxel?
I have metastatic, hormone sensitive PC, that has spread to my spine, shoulder and hips. I started with Lupron and Abiraterone 2.5 years ago. I went through a cycle of docytaxel as well. I've continued with Lupron and Abiraterone, but have replaced Lupron with Estradiol Patches about two months ago. My PSA has been close to zero. I do have the Braca2 gene defect.
I've not read anything about repeating the docytaxel treatment. Is it a consideration to repeat it after a few years? Or has the body had enough damage with one cycle?
My doctors think that if the current treatment stops working the next step for me would be a Parp inhibitor.
My chief side effects have been loss of lean muscle mass, weakness, fatigue and osteopenia. From what I've read, the osteopenia will probably be reversed with Estradiol.
Should the chemotherapy be repeated? How often?
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You ask: What is yours after Pluvicto Did it kill cancer What is your prognosis and OS Overall Survival
Be aware that Pluvicto works really well for 33% of people OK for 33% of people and not at all for 33% of people. If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto. To find out if you’ve got Genetic changes Due to the cancer.
Pluvicto genetic issues
RB1, PTen, TP53 are Pluvicto resistant
ATM & BRCA work better with Pluvicto
The results of pluvicto are all over the place, how long will it extend life can’t be predicted, just like the life expectancy of a cancer patient.
Have you had hereditary genetic testing? Has it been offered to you by a doctor? You can get it done free with the below link, if you live in the United States. Do not check the box that you want your doctor involved or they won’t send you the kit until they get in contact with your doctor. It takes about three weeks to get the results and then a genetic counselor will call you.
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Prostatecancerpromise.org
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1 ReactionYes I have had the test and no hereditary issues
I hear LU 177 gives 4 more moths form 11 to 15 months from date started yet again read elsewhere 24 months plus @northernhiker for comment
Also consider 'spot radiotherapy' (SBRT) for oligometastatic disease which is less than five lesions.
Yes I had L2 radiate 1 inch out in 2020
Today I meet Radiologist to see about palliative radiation on my back left shoulder bone so I can sleep at night Been three months of pain PSA 410 now Abiraterone not working??
Since abiraterone stopped working have you stopped taking it and moved on to another drug? In some cases a lutamide might work to keep your PSA down again. It sure worked for me to switch from Zytiga to Darolutamide.
Oncologist keeping me on Abiraterone then maybe LU 177in 2026 as I qualify
Getting radiation to left back shoulder blade hip at socket T 7 to 4 L 4 on Friday 4th CVH Tattoos done today
If abiraterone has failed you it doesn’t make much sense to continue using it. To continue using it for more than a year, doesn’t make sense at all. ‘
Even if you are getting Pluvicto.
Where are you being treated? Maybe you need a second opinion. Is your oncologist a Genito urinary oncologist? Those are the ones that specialize in prostate cancer.
Seems like there is a bit of message drift.
I have Hormone-Sensitive PC. Estradiol (instead of Lupron), Abiraterone, and Prednasone are keeping my PSA unmeasurable.
I had a cycle of docytaxel about a year ago. If I'm keeping the PC in check, should one consider a second round of chemo?
I forgot to hit reply, the reply was for melcanada.
@wauserfriendly, what did you decide with your cancer team? Will you repeat a cycle of docytaxel or move to a PARP inhibitor?