Severe Neuropathy in legs and feet and not a diabetic or alcoholic

I just finished chemo, same problem. I am waiting to see if it betters itself given some time.

I'm 75 and on hormone therapy for prostate cancer. I've also had back surgery because the neurosurgeons believed a pinched nerve was the cause of my neuropathy. Surgery was no help.
I started taking Pregabalin (3 -75 mg capsules a day) and it did not help reduce my leg pain. I'm now taking pregabalin (6 - 75 mg capsules a day), 1,200 mg Alpha Lipoic Acid and 10,000mg B-12. I stopped drinking alcohol 19 months ago. The Neuropathy pain is better but not gone. I've also tried 2 different antidepressants - one made the pain worst and the other made me dizzy. Note at the pregabalin dose I'm taking it's considered a controlled substance and required preapproval by my insurance.

You went through all of the tests at Mayo and they did not find anything that could help you? I was considering going to Mayo!!

Excessive doses of Statins have caused my Neuropathy, as I had a serious reaction to 40mg of Lipitor and the doctor in Australia Dr Rajappa increased the dose to 40mg of Crestor.
I was a low-risk patient and should not have been prescribed such doses with my moderate cholesterol reading.

I just had it done and it did not work. NOW, they want to do a lumbar TFESI.

As you have been/were active, try physical therapy for stenosis. I am surprised at how much my pt for stenosis has helped.

I have had streoids for spondloythesus for years. Neuropathy started being a issue i has steroid shot at my spine clinic and he told me it wouldnt help the neuropathy. I moved this year and 3 weeks ago i had one that relieved most pain and tingling ftom back toes before i left the clinic. Dr said it wouldnt help numbness. I already have tingling in my toes and pain occassionally in my back. I suppose everyone is different

I assume you saw a neurologist. Did they do a skin punch biopsy to test you for small fiber peripheral neuropathy? This would include doing an EMG test on your legs and feet (or wherever you have symptoms) and nerve conduction velocity test and also blood tests to rule out any auto-immune causes, and some genetic marker tests also. They should also check your B12 and B6 levels.

My peripheral neuropathy is actually caused by a pre-cancerous blood cell disorder, discovered by my neurologist and a hematologist doing extensive blood tests - peripheral smear, ANA, and other more specific tests to make sure that my blood cells looked normal in shape, size, etc. also. If you eat a fast food or high processed food diet, eat processed sugar, drink caffeine and eat fried foods, they can all contribute to increased symptoms with neuropathy, regardless of the cause.

I have diabetic neuropathy and in feet, hands and plus lower back pain. Neurologist put me on gabapentin. 300 MG at bedtime. Now I am suffering with severe leg cramps when I am sleeping.
I also have tremors in my left hand.
Any suggestions???

Sometimes the remedy is as simple as making sure you are well hydrated with water (adding a couple of drops of lemon juice helps me to be more motivated). Also, my P.T. told me the leg cramps are often because your electrolytes are too low. Drinking a sugary beverage with electrolytes, however, is discouraged. I hope you are able to find a solution!