Scan after Pluvicto

Posted by glt @glt, 3 days ago

I have been following Pluvicto discussions. Has anyone had a scan after Pluvicto and if so was there improvement?

Thank you

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Just to clarify: are you asking if anyone has had a scan after completing all six infusions of Pluvicto? I know the treatment protocol at Mayo Rochester includes a C-11 Choline PET scan or a PSMA PET scan six weeks or three months after the 6th treatment. My husband is about to have only his fifth infusion, so we aren't at that point yet.
He does have a SPECT scan the morning after every infusion to see how well the treatment was delivered to the targeted cancer spots; all of those have shown that the Pluvicto is hitting its targets. An interim PSMA PET scan showed the volume of the cancer lesions has been reduced by the treatments given up to that point. So all in all, we are encouraged.
You might want to look at the Pluvicto-specific discussions available under the Prostate Cancer topic for posts by men who have completed all six treatments.

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Yes, scan prior to treatment to see if it may work.
Scan after #1 to check uptake areas.
Scan after #4 showed improvement.
Scan after #6 (5weeks out)
PSA was 10+ during 3 rounds of chemo.
PSA 0.22 last week, coming down since Pluvicto

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Thank you. Did scans indicate an improvement in bone Metastasis?

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@lag

Just to clarify: are you asking if anyone has had a scan after completing all six infusions of Pluvicto? I know the treatment protocol at Mayo Rochester includes a C-11 Choline PET scan or a PSMA PET scan six weeks or three months after the 6th treatment. My husband is about to have only his fifth infusion, so we aren't at that point yet.
He does have a SPECT scan the morning after every infusion to see how well the treatment was delivered to the targeted cancer spots; all of those have shown that the Pluvicto is hitting its targets. An interim PSMA PET scan showed the volume of the cancer lesions has been reduced by the treatments given up to that point. So all in all, we are encouraged.
You might want to look at the Pluvicto-specific discussions available under the Prostate Cancer topic for posts by men who have completed all six treatments.

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Thank you so much. I am going through the Docetaxel series now and may be on Pluvicto at some point.

Was your husband on Docetaxel before Pluvicto?

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@lag

Just to clarify: are you asking if anyone has had a scan after completing all six infusions of Pluvicto? I know the treatment protocol at Mayo Rochester includes a C-11 Choline PET scan or a PSMA PET scan six weeks or three months after the 6th treatment. My husband is about to have only his fifth infusion, so we aren't at that point yet.
He does have a SPECT scan the morning after every infusion to see how well the treatment was delivered to the targeted cancer spots; all of those have shown that the Pluvicto is hitting its targets. An interim PSMA PET scan showed the volume of the cancer lesions has been reduced by the treatments given up to that point. So all in all, we are encouraged.
You might want to look at the Pluvicto-specific discussions available under the Prostate Cancer topic for posts by men who have completed all six treatments.

Jump to this post

Yes, after six infusions. I have not found anyone on this site who have had all 6 injections then scans. However, some have had interim scans which look encouraging. This site is invaluable to us with mCRPC.
Thank you all.

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@glt

Yes, after six infusions. I have not found anyone on this site who have had all 6 injections then scans. However, some have had interim scans which look encouraging. This site is invaluable to us with mCRPC.
Thank you all.

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If you do a search of the Prostate Cancer forum for "Pluvicto," it will return several discussions, including some posts by men who have had all 6 infusions.

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@glt

Thank you. Did scans indicate an improvement in bone Metastasis?

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I think you are asking kbrz, but I can reply also, to say that the SPECT scans after each infusion and the PSMA PET scan after infusion #4 all showed decreased volume in the bone metastases in my husband.

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@lag

I think you are asking kbrz, but I can reply also, to say that the SPECT scans after each infusion and the PSMA PET scan after infusion #4 all showed decreased volume in the bone metastases in my husband.

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Good news. Happy for you and your husband. Thank you.

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@glt

Thank you so much. I am going through the Docetaxel series now and may be on Pluvicto at some point.

Was your husband on Docetaxel before Pluvicto?

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My husband had chemotherapy with docetaxel way back in 2016, after the prostate cancer became systemic and started popping up on his spine in several places faster than Radiation Oncology could zap them. The docetaxel worked very well; after it ended in August 2016 and up until spring 2023, he needed only spot radiation and oral medications such as Zytiga plus Lupron shots to keep the cancer quiet. In December 2023 the cancer spots had become so numerous and widespread that Dr. Kwon at Mayo Rochester ordered the PSMA PET scan and discovered that Lu177/Pluvicto was both warranted and likely to be successful. My husband began Pluvicto infusions in January 2024. No one said he had to have more chemo before he could start Pluvicto, I assume because it was in his history. Plus they have pretty much stopped requiring chemo before Pluvicto will be authorized.

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@lag

Just to clarify: are you asking if anyone has had a scan after completing all six infusions of Pluvicto? I know the treatment protocol at Mayo Rochester includes a C-11 Choline PET scan or a PSMA PET scan six weeks or three months after the 6th treatment. My husband is about to have only his fifth infusion, so we aren't at that point yet.
He does have a SPECT scan the morning after every infusion to see how well the treatment was delivered to the targeted cancer spots; all of those have shown that the Pluvicto is hitting its targets. An interim PSMA PET scan showed the volume of the cancer lesions has been reduced by the treatments given up to that point. So all in all, we are encouraged.
You might want to look at the Pluvicto-specific discussions available under the Prostate Cancer topic for posts by men who have completed all six treatments.

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Russ is in his 2 nd ! Very pleased 😀 Thanku 🙏

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