Savella for Peripheral Neuropathy?

Posted by cwallen9 @cwallen9, Mar 17, 2019

Has anyone used and had success with Savella for Peripheral Neuropathy? My pain management doctor recommended it. I have just started and do not have any results yet (still on very small dose).

Hi @cwallen9, I don't have pain with my neuropathy just the numbness. I'm hoping someone that has experience will be able to share it with you. I was able to find some information that may be helpful.

Lyrica, Cymbalta and Savella: Do They Work?
https://www.painnewsnetwork.org/stories/2017/3/27/lyrica-cymbalta-savella-do-they-work

Milnacipran for pain in fibromyalgia in adults.
https://www.ncbi.nlm.nih.gov/pubmed/26482422

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Hi, @cwallen9 – a few Connect members who've had mentioned milnacipran (Savella) for relief of fibromyalgia or other types of pain may have some input on its potential use for your peripheral neuropathy pain and share how it's worked in their situations, like @lioness @kaylg57 @pharis022 @jdrhoads @jmmb.

You mentioned no results yet with the milnacipran (Savella) as you just started on a very small dose. Have you noted any side effects?

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Thanks for your reply. Yes, I have experienced severe side effects and have stopped it after only 5 days. It acted like a stimulant and made my neuropathy pain worse. It also made it more difficult to sleep. After discussing with my Pain Management Doctor, she agreed that I should go off it. I am now trying Elavil to complement the Gabapentin that I have been on for several months. I have only tried it for one day, but so far so good.

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@lisalucier

Hi, @cwallen9 – a few Connect members who've had mentioned milnacipran (Savella) for relief of fibromyalgia or other types of pain may have some input on its potential use for your peripheral neuropathy pain and share how it's worked in their situations, like @lioness @kaylg57 @pharis022 @jdrhoads @jmmb.

You mentioned no results yet with the milnacipran (Savella) as you just started on a very small dose. Have you noted any side effects?

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@cwallen9 Thank you Lisa I'm afraid I can't be to much help I was out on Savella awhile ago but went of it very soon after it didn't seem to be helping but to long ago to remember I know I didn't have any side effects

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Hi unfortunately I wasn't on Savella long. I was weaning off my Cymbalta and going on the Savella. I wasn't feeling well so I just stuck with the Savella. I don't know if it was from the Cymbalta withdrawal.

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@peggyn

Has anyone taken savella for their neuropathy? I have never heard of it, but I met a lady the other day and that is what she takes. She said she had done them all and this one worked the best for her.. She sais it totally stops the burning in her feet.

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Hi Peggy @peggyn, You might get a better response to your question if you posted it in the neuropathy discussion where more members will see your post:

> Groups > Neuropathy > Living with Neuropathy – Welcome to the group
https://connect.mayoclinic.org/discussion/living-with-neuropathy-welcome-to-the-group/

Here are a few articles that may provide some information on Savella (Milnacipran) that might be helpful for you.

Milnacipran for neuropathic pain in adults
https://www.cochrane.org/CD011789/SYMPT_milnacipran-neuropathic-pain-adults

Milnacipran for neuropathic pain in adults (Review) – Cochrane Library (PDF)
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011789/epdf/full

Are you considering using Savella for treatment?

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Has anyone taken savella for their neuropathy? I have never heard of it, but I met a lady the other day and that is what she takes. She said she had done them all and this one worked the best for her.. She sais it totally stops the burning in her feet.

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Hi @peggyn you may have noticed I moved your post to this discussion on savella for peripheral neuropathy so that you can connect with others who have similar experiences. Simply click VIEW & REPLY in your email notification to get to your post.

I wanted to thank @johnbishop for responding to your post, and also wanted to tag fellow Connect members @cwallen9 @kaylg57 @pharis022 and @jdrhoads as they have mentioned savella in the past and may be able to offer you support.

What are you currently on? How effective or ineffective is it? Have you started looking into setting up an appointment with your doctor to get their opinion?

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I'm on lyrcia now..Sometimes I'm not sure it works as good as it could. I haven't mentioned to my dr. yet, as this lady just told me how much it helped her the other day.

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@peggyn

Has anyone taken savella for their neuropathy? I have never heard of it, but I met a lady the other day and that is what she takes. She said she had done them all and this one worked the best for her.. She sais it totally stops the burning in her feet.

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I tried every different medication out the from Gabapentins to Cymbalta etc & all of those affected me terribly where my head was in one spot & my body was halfway across the room somewhere or I was having terrible dreams & having fits of anger at people. The Gabapentin had me so off balance I fell & broke my hip. I then started out on Topiramate which helped with the electric shock feeling of neuropathy a bit but not near enough. I asked to try something else, anything so Savella came next, didn't seem to do much @ 25mg 2x a day so I experimented with 50mg 2x a day, spoke to my doc about further experimenting, it was okayed, so now I'm up to 300mg per day, 100mg 3x a day. This dose has helped allot in reducing the burning sensations, the electric shock sensations. They are still there tho, just not near as bad & some days it's still hard to get them to a tolerable level where I can comfortably stand or walk around & accomplish some household chores etc. Most days I've been just unable to do much or even leave my house cause of the pain & numbness, now I'm not having to 'force' myself to do things so much. It does nothing for the numbness tho. Hope this helps anyone considering Savella, that likely you need to reach the higher does levels in order to achieve any relief results, please keep trying it. I've not yet experienced any side effects. I feel I could go up more in doseage but will wait to meet with my neurologist or msg her before I do on my own.

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@blt054

I tried every different medication out the from Gabapentins to Cymbalta etc & all of those affected me terribly where my head was in one spot & my body was halfway across the room somewhere or I was having terrible dreams & having fits of anger at people. The Gabapentin had me so off balance I fell & broke my hip. I then started out on Topiramate which helped with the electric shock feeling of neuropathy a bit but not near enough. I asked to try something else, anything so Savella came next, didn't seem to do much @ 25mg 2x a day so I experimented with 50mg 2x a day, spoke to my doc about further experimenting, it was okayed, so now I'm up to 300mg per day, 100mg 3x a day. This dose has helped allot in reducing the burning sensations, the electric shock sensations. They are still there tho, just not near as bad & some days it's still hard to get them to a tolerable level where I can comfortably stand or walk around & accomplish some household chores etc. Most days I've been just unable to do much or even leave my house cause of the pain & numbness, now I'm not having to 'force' myself to do things so much. It does nothing for the numbness tho. Hope this helps anyone considering Savella, that likely you need to reach the higher does levels in order to achieve any relief results, please keep trying it. I've not yet experienced any side effects. I feel I could go up more in doseage but will wait to meet with my neurologist or msg her before I do on my own.

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Hello @blt054, Welcome to Connect. Thanks for sharing what helps you. There are a few other discussions you might also find helpful.

— Member Neuropathy Journey Stories: What's Yours?: https://connect.mayoclinic.org/discussion/member-neuoropathy-journey-stories-whats-yours/
— Myofascial Release Therapy (MFR) for treating compression and pain: https://connect.mayoclinic.org/discussion/myofascial-release-therapy-mfr-for-treating-compression-and-pain/

Are you able to share a little more about your neuropathy diagnosis?

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@johnbishop

Hello @blt054, Welcome to Connect. Thanks for sharing what helps you. There are a few other discussions you might also find helpful.

— Member Neuropathy Journey Stories: What's Yours?: https://connect.mayoclinic.org/discussion/member-neuoropathy-journey-stories-whats-yours/
— Myofascial Release Therapy (MFR) for treating compression and pain: https://connect.mayoclinic.org/discussion/myofascial-release-therapy-mfr-for-treating-compression-and-pain/

Are you able to share a little more about your neuropathy diagnosis?

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Hi, thank you for the info! Well, allot is still up in the air sort of. I also have Hep C which may or may not be a contributing factor. Also, Mayo thru blood samples submitted by one nuerologist determined that I have a blood disorder called Cryglobulemia. It has something to do with when my body temp falls below a certain level it causes the platlettes to gather together instead of staying spread out like normal. I don't really understand it well, I just know I get cold very easy & have to be careful of hands & feet not being able to feel them well. Even hot things, I've burned my hands on hot coffee mugs, hot pans, as well sitting for long periods of time my feet get overly cold & I don't realize how cold they really are. I'm proceeding soon with a treatment program for the Hep C. I'm 67, I have scoliosis, allot of degenerative spinal issues. Have had lower lumbar surgery in which the bone canals going down into the legs were drilled out to widen to make more room for the nerves & I think at least 1 vertabrae was taken out. Since that surgery I did have a fall breaking my right hip, thanks to the medications messing my balance up so bad. I've not been given a clear diagnosis. I also have problems with my cervical (neck) spinal area & have had injections to relieve numbness/tingling there, although it has gotten worse down both arms & I sometimes feel it in my face & across my lips/cheeks. I'm scheduled to see Dr. Lawson Neurologist @ Dartmouth Hitchcock Lebanon, N.H. in Oct starting out with EMG studies & moving on from there. In my area doctor appt's are very hard to get, booked out many months in advance. I don't know how or if the Cryglobulemia plays a part in Neuropathy or not. I suppose it's something each person would need to bring up to their own doctor & ask to have their blood tested for. It would be interesting to know how many have the same?

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