Anyone participate in RMC9805 and RMC6236 clinical trials?

Hi @gnest, your can read more about histotripsy for liver metastases in
- Has anyone out there tried Histotripsy for tumors in the liver?https://connect.mayoclinic.org/discussion/histotripsy-1/
- I recently learned of histotripsy treatment for metastatic NETs https://connect.mayoclinic.org/discussion/i-have-recently-learned-of-a-treatment-for-metastatic-neuroendocrine/

Did your mom decide to take part in the clinical trial?

Yes. I am on the RMC trial combo for 6236/9805. I just completed my 4th cycle (every cycle is 3 weeks). I have had an excellent early response with the 1.6cm lesion in my liver and 1.5 cm lesion in my abdomen near my left adrenal gland are too small to measure as of yesterday’s CT scan. My doctor said this is an unusually good response. The side effects are challenging (facial rash that bleeds, scalp sores, mouth sores, diarrhea) but not nearly as difficult as the folfirinox side effects. Doctor has made clear it is not a cure but could extend my life by some time. Let me know if I can answer any other questions.

Thank you @mimimmx for your response and sharing your experience. I am glad the treatment works for you. It gives us some hope.
We understand it is not a cure. Hopefully it will be a long-term treatment.
We are waiting for a screening eligibility for this clinical trail.

My mom worries a lot about facial rash. Is there any cream that helps with the rash?

What is nausea situation? Nausea was the main side effect she experienced during prior chemo treatments, so she worries about nausea.

Does it effect your appetite? She barely eat anything now. I worry how the new pills will effect the appetite.

Thanks again

Thank you Colleen for providing the information about the histotripsy.

The facial rash is treated proactively with doxycycline and an acne gel applied twice a day. My understanding is that different participants have different levels of severity. Mine was pretty severe to start but after the first two cycles really moderated. Unfortunately, the doxycycline can also be hard on your stomach. My appetite has been modestly suppressed, I eat more frequent, smaller meals. I have only lost a couple pounds since being in the trial. My only nausea has happened when I eat too much too fast. They do prescribe Kytril for nausea. My understanding is that other participants may have had more challenges with nausea. If she is accepted in the trial, there is a Facebook chat group for trial participants that has been helpful to share information. I assume she is KRAS G12D positive. You may want to check out the Facebook Group “KRAS Kickers” and “KRAS G12D Kickers”. Lots of good information being shared across multiple cancer types with the KRAS mutation.

Thank you @mimimmx for providing such a detailed information. I will check the Facebook group.

Good morning. My mother suffers from inoperable pancreatic cancer. There are no metastases. We live in Poland. Is it possible to include it in the RMC9805 / RMC6236 clinical trail? How long does the treatment last, how many cycles does it consist of and what would the cost be (including possible diagnostics for these mutations)? Thank you in advance for any information.
Matthew

Revolution Medicines’ clinical trials for RMC-6236 and RMC-9805 primarily focus on patients with advanced or metastatic pancreatic ductal adenocarcinoma (PDAC). The RMC-9805-001 Phase 1/1b study, for instance, is designed to evaluate RMC-9805 in patients with advanced solid tumors harboring a KRAS G12D mutation.  Similarly, the RMC-6236-001 Phase 1/1b trial is assessing RMC-6236 in patients with advanced solid tumors bearing KRAS G12 mutations. 

While the available information indicates a focus on advanced or metastatic cases, specific eligibility criteria regarding the inclusion of non-metastatic pancreatic cancer patients are not explicitly detailed in the provided sources. Advanced solid tumors generally refers to cancers that at present are not considered curable, and they don’t have to be non-metastatic to be considered non-curable. So stage III locally advanced may be a possibility for inclusion. Stage I or II would not be eligible for inclusion in these trials. For precise eligibility requirements, it would be best to consult the official clinical trial listings or contact Revolution Medicines directly. Contact information is on their website or under the trial descriptors found on clinicaltrials.gov, look up a site in the list of participating medical centers and contact the P.I. In charge of the trial to ask whether the trial will accept lower-staged patients at this time.

I am also on the trial, cycle 10! My cohort is 1200mg RM 9805-KRAS G12D (the max dose) and as of this cycle, 200 mg RM 6236 (pan KRAS). Skin nuisances, mostly on my face but also randomly on fingers. Basically, it really dries your scalp so some little sores appeared there. The face is more irritating, because it creates tiny white blisters. Doxycline doesn't help me much, but I do try to use the gel twice/day. It dries everything up which creates more issues. So I use Vitamin C/E oil and some serums. Basically, a little nausea for about 30 min after taking it then life as normal. The side effects are FAR different than the chemos we all know.

I am in phase 1b which has select dosing requirements different than the other cohorts. RM6236 is getting tons of attention and it looks to be moving rapidly into phase 3. Some sites are administering it to first line patients with Gem/Abraxane.

Revolution Medicine will be of very little help, if at all. Call the sites listed as hosting their trials for details about which cohort they may be registering. Feel free to reach out to me, also, if I can answer any questions. I am in trial at Carolina BioOncology in NC.

Thank you for your sharing! I would like to ask whether 6236 should be taken all the time or will it rest for a period of time after 21 days?