Rising PSA years after radical prostatectomy

PSA seems to be very stable just continue to do regular PSA checks possibly residual prostate tissue?

To me that doesn’t seem to make sense retest and see what that is.

I might add that I had 39 rp right after surgery. I found that I had radiation cystitis afterward and as I was on eliquis for Afib i ended up getting a watchman device in my heart to stop the bladder bleeding. It kind of worked as ThE bleeding has stopped. Right after the prostatectomy the nurse was irrigating my Foley bag on The wrong side and it ended up blowing up inside my bladder. It took a long time to get this settled out and it made it so I had a very hard time holding my urine during radiation. This whole thing has been a crazy mess for me.

Mine went up from several years being <.1 to .2, then .3 and I'm receiving radiation treatment. I had an inconclusive psma pet scan. saw a little something (Type 3 inconclusive) on a lymph node so they're including that. I'm also taking a hormone called Orgovyx for 6 months. I'm 61, was 54 at rp. Best wishes.

Thanks for sharing. I had 25 doses of radiation and put on biculatamide 150mg daily for 18 months. Iam in the in the 7th month of the medication. I started with biculatamide on 7th september and radiation on 19th sept. 2 and ended radiation on 22 oct. Then on 14th Dec I had a test and PSA was not detectable. Then on 24th Jan. my urologist requested another test and it was same undetecable. Wil be going for another test on 30th May and then a review with urologist in October

The drug has had side effects - weakness, oedema at the lower foot especially by evening times. I am able to walk about 5-6km daily and visit the gym 3 times a week. There has been a little weight loss. Little loss of erection but this varies. At times I do not even need any aid to maintain erection.

My biggest challenge now is a bit of pain in the right groin which comes on and off.

Wish you the best.

I was told by my medical team .2 was generally considered recurrence. Mine rose to that and I'm getting radiation presently. I waited approx 6 weeks and it rose to .3!

I recently had an elevated PSA after a period of time from RP. PSA went from <.1 to .2 then second test 6 weeks later was .3. I'm getting 38 doses of radiation now with 6 months of Orgovyx oral hormone therapy.

Welcome, @jrp. I can imagine you are alarmed. There can be a number of things that contribute to a rise in PSA. I wrote more about it earlier in this discussion. You can jump to my comment here: https://connect.mayoclinic.org/comment/335976/

I just got my results of rising PSA. I had a Radical Prostatectomy in June 2019. My PSAs were .001, then .009, again.009, and now have jumped to .77. We are obviously upset Doctor says we can take another test in 10 weeks followed by a pet scan. I am hoping my medications to be a cause of this rise as I just stated Hydrochlorothiazide 25mg and Oxybutynin Chloride Er for symptoms. Thoughts?

I do a 3T MRI every year.