Reclast infusion long term side effects

Posted by tiza @tiza, Feb 4 7:41am

Hello,
I’m new to this forum.
I had a Reclast Infusion in May 2025. After a year dealing with knee pain issues my Dexa Scan results were terrible.
My endocrinologist had already suggested I’d need it, after doing some research I refused it for about 5 years.
Since the infusion, I’ve had digestive problems and pain on my left ribs. Strangely, on the first 24 hours after the infusion this is the exact place where I had intense sharp pain. It’s mostly during the night and in the morning.
Anyone experiencing the same?
Thank you!

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dannyandebbie, thank you, again. I'd wondered if the steroid wouldn't have to be given early in the adverse response. What was the timing of the steroid for you. Was it difficult to obtain. Are your kidneys involved.
No doubt your willingness to tell us about your experience with Reclast has saved some a similar reaction.
To hear the long term consequences is sad, and provides caution. There have been many lawsuits against Novartis because of this drug. I pray you get resolution of this long lasting pain.
We are supposed to be able to trust our doctors. Many of them actively discourage any patient research, laughing at the google "rabbit hole." Some doctors encourage research even providing links to reliable research. We tend to trust our doctors, tolerate side effects and then blame ourselves.
I hope you keep posting. It is unusual to hear long term effects. Your generosity is deeply appreciated.

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Profile picture for lollyb @lollyb

I’m glad to find this forum, and sad to hear that Reclast long term side effects are a thing. 63 (F), height loss of 1” in a year, -2.7 lumbar score—thus Reclast.
I’m six days out from my first infusion. Ten hours after infusion I had chills, a fever of 101, nausea and vomiting, intense shoulder pain, and overall muscle and joint pain. Couldn’t leave the house the next day. Symptoms continued and I went to ER where they insisted I probably had the flu, so tested me. Negative, of course. Also gave me a CAT scan because I had stomach pain—at least they gave me Zofran first. But the fluids I was desperate for came only 3 hours later.
Day 6, appetite poor, slight nausea, low grade fever, total exhaustion.
I feel like this isn’t getting better anytime soon. Will ask for blood work next week if there’s not significant improvement.
Interesting: I asked the infusion nurse if I could get a bag of fluids after the infusion, knowing dehydration was a possible side effect. She said they used to do that before Covid, when fluids got scarce. They never resumed them because they were expensive and “nobody died” without them.
I hear your all’s frustration about Drs insisting symptoms aren’t related. Keep pushing to be listened to. Refuse to be pushed aside.

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@lollyb I always get the fluid bag first! No problem for me. I just had my second infusion last week,

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I had heartburn, hip, back pain in my bones for a year after my Reclast infusion. After a year the ache and pain went away. I took all the precautions suggested before an infusion. This pain came on a month or so after the infusion. No, I haven't’ gotten a second infusion.

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I trusted my doctor and had 3 infusions. Instead of feeling better, I fell the first year and broke 2 ribs on my left side, I thought well the medication had not had time to make a difference.
2 years later, being last summer, I tripped twice, been hospitalized twice, first time broke 3 ribs on my right side, a few months later, fell again broke 2 more ribs on my right side. I am very distraught and now it’s too late. Damage has been done 🥲 I just pray that I don’t break anymore parts of my body

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Profile picture for kmketter @kmketter

@lollyb I always get the fluid bag first! No problem for me. I just had my second infusion last week,

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@kmketter If I may ask, what is your height & weight? I'm very small and thin. I've been prescribed Reclast but the more I learn the more hesitant I become, so I'm trying to get more information before starting. thank you.,Sarah

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Profile picture for shmbrd @shmbrd

@kmketter If I may ask, what is your height & weight? I'm very small and thin. I've been prescribed Reclast but the more I learn the more hesitant I become, so I'm trying to get more information before starting. thank you.,Sarah

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@shmbrd not sure if you were asking me or KMKetter; I’m a male, 5’2” around 119 weight. 21 months out and continue symptoms from my infusion. My endocrinologist says it is not from the infusion, I say it is….did not have these symptoms ( shoulders and left foot pain, fatigue, nausea and aches and burning in my lower backside). I have Ankolosing spondylitis (50 years) and have had bladder cancer 5 times over the past 16 years. Retirement two years ago and was feeling pretty good until infusion. My endocrinologist say I need additional infusion, Reclast did not cause these symptoms, sent me to rheumatologist, who sent me to neurologist; both had no explanation for my symptoms. I go to physical therapy bi-weekly, helps some….just try to stay positive and as active as I possibly can! Best of luck!

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Profile picture for dannyandebbie @dannyandebbie

@shmbrd not sure if you were asking me or KMKetter; I’m a male, 5’2” around 119 weight. 21 months out and continue symptoms from my infusion. My endocrinologist says it is not from the infusion, I say it is….did not have these symptoms ( shoulders and left foot pain, fatigue, nausea and aches and burning in my lower backside). I have Ankolosing spondylitis (50 years) and have had bladder cancer 5 times over the past 16 years. Retirement two years ago and was feeling pretty good until infusion. My endocrinologist say I need additional infusion, Reclast did not cause these symptoms, sent me to rheumatologist, who sent me to neurologist; both had no explanation for my symptoms. I go to physical therapy bi-weekly, helps some….just try to stay positive and as active as I possibly can! Best of luck!

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@dannyandebbie Thanks for taking time to reply. Take good care of yourself, I hope your symptoms will lighten soon.

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Profile picture for shmbrd @shmbrd

@dannyandebbie Thanks for taking time to reply. Take good care of yourself, I hope your symptoms will lighten soon.

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@shmbrd seems the more I use my arms or foot the next day I pay for it, hopefully time heals all wounds!

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Profile picture for daisy17 @daisy17

@dannyandebbie I read so many statements from women on this site who experience side effects from various bone medications, while their doctors insist their symptoms are not related to the drug. I don't understand how the doctors can be so uninformed. A quick google search shows many sites, such as Drugs . com that include a long list of side effects.

This is from AI Assist: "Common side effects of Reclast (zoledronic acid) include flu-like symptoms such as fever and chills, headache, and bone, muscle, or joint pain. Serious side effects can include severe allergic reactions, kidney problems, and unusual fractures, so it's important to monitor for any concerning symptoms and consult your doctor."

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@daisy17 I had my reclast last Friday. Its been 1 week today.My joint and bone pain has been unbearable. I went to the DR today she blamed the antibiotics I was taking. I came home and looked it up, there is no real interaction with the 2 drugs. I cried like a baby, I can't bend my fingers or close my hands. It also caused me to have an eye ulcer and that is why the antibiotics.
If they would read, it says severe bone pain and muscle pain.
I told my husband we all have to take care of ourself because they don't anymore.

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Profile picture for penny57 @penny57

@daisy17 I had my reclast last Friday. Its been 1 week today.My joint and bone pain has been unbearable. I went to the DR today she blamed the antibiotics I was taking. I came home and looked it up, there is no real interaction with the 2 drugs. I cried like a baby, I can't bend my fingers or close my hands. It also caused me to have an eye ulcer and that is why the antibiotics.
If they would read, it says severe bone pain and muscle pain.
I told my husband we all have to take care of ourself because they don't anymore.

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@penny57
I’m so sorry… this is so recurrent
We need to create a data base of these cases and report it to the FDA or the Drug Company.
I hope you feel better.

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