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PSA went from 3 to 5 in 9 months, but MRI was negative for cancer

Posted by cspringford @cspringford, 5 days ago

I have had multiple (6-8) MRI's and Biopsys since 2016 following a Gleason 6 score. All were clear. I also had aquablation surgery in January of 2025 to relieve pressure. Post Op tissue was biopsied and clear. PSA was measured again in February of 2025 at 2.75 and again in December of 2025 at 5.2. I had another negative MRI today. Dr told me in December of 2025 that the numbers are going up too fast to be BPH. He said cancer or an infection. I have neither of those. Why is my PSA going up at this rate if my only symptoms indicate BPH? Can BPH related PSA scores increase at this rate?

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jeff Marchi | @jeffmarc | 3 days ago
In reply to @cspringford "Same area for the pirads. The Gleason 6 never showed up on ANY of the MRI's...." + (show)
Profile picture for cspringford @cspringford

Same area for the pirads. The Gleason 6 never showed up on ANY of the MRI's. It was visible on the first biopsy taken 10 years ago. a single dot on a golf ball. I have had 6-8 MRI's and about the same number of biopsies since 2016. ALL have been clear of any cancer. It seems like BPH is the only concern, but the doctor says that the PSA is rising too rapidly for that. We just keep going in circles. More MRI's and biopsies, same clear results. That is good, but if the doctor believes that there is an underlying problem, then what is it? It obviously isn't prostate cancer or they would have discovered it by now.

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@cspringford
Fqrequently high Gleason score results from a biopsy will show cancer that was not visible in the MRI.

A PSE test can tell you whether or not you have cancer in your body when the MRI shows nothing but your PSA is rising.

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jc76 | @jc76 | 1 day ago

@cspringford
None of us our medical doctors so what we post should come from our experiences with this disease.

I don't want to discount your doctors. But getting an infection in the prostate can really do rise in PSA. Heck even things like agressive biker riding and aggressive sex have been documented to causing PSA to rise. So you can see if you have ongoing BPH or an infection your PSA is really going to react to it.

You said you had neither BPH or infection. How do you know this. Did you have urine test, DRE, etc.?

A MRI does not confirm cancer. It can show lesions, tumors, suspicious areas. It is the biopsy that confirms. Did I read your posts that you do have BPH symptoms?

Are you seeing a urologist? I hope for you it is BPH or infection. But don't think you are going to know until they do more test to see how to treat. May require another biopsy but from what I read you have BPH symptoms to rule out cancer. But if you have BPH alone a biopsy even if negative probably going to irritate the prostate even more.

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