PSA undetectable!

Posted by psychometric @psychometric, Oct 3, 2025

PSA < 0.1 ng/mL on my first test since my RARP on June 18th. Labcorp (non-ultra) test using Roche ECLIA methodology. It's only the first result of many tests to come, but I'll take it!

Initial PSA: 6.68.
Pathologic Gleason Score was 3 + 4.
Grade Group: 2.
Biopsy Gleason Score was 3 + 4.
Pathologic Stage: pT3bN0M0R0.
Positive Margins: No.
Cribriform Histology: Yes.
Intraductal Histology: No.
Number of Lymph Nodes Removed: 15.
Number of Positive Lymph Nodes: 0.
Unfavorable histology: Present (Less than 10%).
Large cribriform pattern 4: Present.
Intraductal carcinoma: Atypical intraductal proliferation, suspicious.
Risk Group: High.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for psychometric @psychometric

@jc76 - nothing too interesting, I studied psychometrics in graduate school.

I asked about a post-op Decipher @jeffmarc and several times about ultra-sensitive PSA tests @brianjarvis and my surgeon at the Cleveland Clinic doesn't think either are necessary. I'm not too sure what the updated Decipher would add since I'm already considered high risk (no BRCA1/2 mutations). I also asked about a referral to a GU/MO but was told that happens if/when PSA > 0.2.

For now, I'll get my PSA tested every three months. If it becomes detectable, I will up my squeaky wheel level considerably.

Jump to this post

@psychometric I have 4+5. At Mayo, I think a Decipher is automatic, probably even for a G7. So I had a Decipher and it came in low risk, which was great since 4+5 is high risk.

So if I were you, and of course I'm not, I'd ask for a Decipher. But note: it is a very expensive test. Mine was fully covered by insurance, plus the company that does Decipher offers payment assistance. But you'd want to investigate and then weigh any costs you might incur vs the value of the information.

REPLY

Interesting - so is Roche Cobas an uPSA test ? Are there specific test names / companies I should be requesting for my PSA test ? I've had both the Roche Cobas and the Beckman Hybritech PSA Assay tests and both have hundreds in the decimal read-out (x.xx)

REPLY

Roche is just one of a number of calibration techniques for PSA testing equipment.
Because there are different calibration techniques, different labs may get different PSA results - which is why it’s often important to use the same lab for PSA testing.

REPLY
Profile picture for rotate @rotate

@psychometric I have 4+5. At Mayo, I think a Decipher is automatic, probably even for a G7. So I had a Decipher and it came in low risk, which was great since 4+5 is high risk.

So if I were you, and of course I'm not, I'd ask for a Decipher. But note: it is a very expensive test. Mine was fully covered by insurance, plus the company that does Decipher offers payment assistance. But you'd want to investigate and then weigh any costs you might incur vs the value of the information.

Jump to this post

@rotate the Decipher test is covered by Medicare for beneficiaries with localized and metastatic prostate cancer. It is included in national guidelines and is the only gene expression test covered by Medicare for all prostate cancer risk levels.

REPLY
Profile picture for trchar @trchar

@rotate the Decipher test is covered by Medicare for beneficiaries with localized and metastatic prostate cancer. It is included in national guidelines and is the only gene expression test covered by Medicare for all prostate cancer risk levels.

Jump to this post

@trchar I should have mentioned that. Medicare paid for mine. But some folks not in Medicare did have to pay. And I don't know about Medicare Advantage.

REPLY
Profile picture for rotate @rotate

@trchar I should have mentioned that. Medicare paid for mine. But some folks not in Medicare did have to pay. And I don't know about Medicare Advantage.

Jump to this post

@rotate I agree I should have added that as well. Like yourself I’m on Medicare with sup. plan G I am so very thankful I have that coverage, I have had both proton radiation and imrt for two small lymph node mets never an issue covering everything.

REPLY

Indeed. I also have G. In over $400,000 of charges to Medicare, I paid nothing.

REPLY

PSA still undetectable (< 0.1) on my second post-surgery test.

REPLY
Please sign in or register to post a reply.