Prostate cancer and Zytiga and ZERO PSA

Posted by spryguy @spryguy, Jan 9, 2023

Has anyone attained undetectable psa while on Zytiga (Abiraterone) ? If so was the Zytiga discontinued at some point (before 24 mos) ?
I was diagnosed with Gleason 7(4+3) w P. lymph nodes metastasis. Completed 39 sessions of IMRT, 10 mos (two 6 mo. Doses) of Lupron , and 5 mos Zytiga.
Initial psa was 80+ and is now undetectable (reached <0.1 ng/ml after 60 days on Zytiga).
What is to be gained by continuing an expensive drug that has so many negative side effects?

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@round5

I don’t necessarily recommend that course. Coming off treatment and letting the poison leave the body for awhile has its benefits,quality of life,feeling better etc. Over treatment is a bad thing too. My plan is still to stay off treatment as long as I can. That’s also the only way to see if one-selves cancer might be in remission. Watch it closely and save the treatment for when it is really needed. I think family members can sometimes be selfish wanting to keep their loved ones as long as possible without looking at the quality of life the person is having. Respect the patients feelings. I hope you are able to both work through this for a mutual decision on treatments.

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Thanks for the comment. I am anxious to try "no treatment " for a while just to see what's going on. Let PSA rise to a level that allows a PSMA SCAN to identify areas of concern. Then any lesions can be treated individually. It's an effective way to continue to "play for time".
The drugs or "treatment " have an evil side both physically and psychological. There are activities that I would like to do but can't due to side effects.

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@round5

I don’t necessarily recommend that course. Coming off treatment and letting the poison leave the body for awhile has its benefits,quality of life,feeling better etc. Over treatment is a bad thing too. My plan is still to stay off treatment as long as I can. That’s also the only way to see if one-selves cancer might be in remission. Watch it closely and save the treatment for when it is really needed. I think family members can sometimes be selfish wanting to keep their loved ones as long as possible without looking at the quality of life the person is having. Respect the patients feelings. I hope you are able to both work through this for a mutual decision on treatments.

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Thank you for your comment, it is appreciated and helpful. Words of wisdom are needed at times.

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@round5

I don’t necessarily recommend that course. Coming off treatment and letting the poison leave the body for awhile has its benefits,quality of life,feeling better etc. Over treatment is a bad thing too. My plan is still to stay off treatment as long as I can. That’s also the only way to see if one-selves cancer might be in remission. Watch it closely and save the treatment for when it is really needed. I think family members can sometimes be selfish wanting to keep their loved ones as long as possible without looking at the quality of life the person is having. Respect the patients feelings. I hope you are able to both work through this for a mutual decision on treatments.

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Thank you for your reply, it is most helpful and your honesty is very much appreciated.

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@round5

I don’t necessarily recommend that course. Coming off treatment and letting the poison leave the body for awhile has its benefits,quality of life,feeling better etc. Over treatment is a bad thing too. My plan is still to stay off treatment as long as I can. That’s also the only way to see if one-selves cancer might be in remission. Watch it closely and save the treatment for when it is really needed. I think family members can sometimes be selfish wanting to keep their loved ones as long as possible without looking at the quality of life the person is having. Respect the patients feelings. I hope you are able to both work through this for a mutual decision on treatments.

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Thank you for your reply. Your words of wisdom are appreciated. You're right, loved ones can be unknowingly selfish. Your advice will be seriously taken.

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@round5

I don’t necessarily recommend that course. Coming off treatment and letting the poison leave the body for awhile has its benefits,quality of life,feeling better etc. Over treatment is a bad thing too. My plan is still to stay off treatment as long as I can. That’s also the only way to see if one-selves cancer might be in remission. Watch it closely and save the treatment for when it is really needed. I think family members can sometimes be selfish wanting to keep their loved ones as long as possible without looking at the quality of life the person is having. Respect the patients feelings. I hope you are able to both work through this for a mutual decision on treatments.

Jump to this post

Thank you for your reply, it is most helpful and beneficial as well. Hard decisions to make at times, yet having this forum helps a great deal. Again, thank you and take good care.

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