Prescribed Tymlos after Evenity

Posted by hollygs @hollygs, Nov 17, 2024

I completed a one year course of Evenity in September 2023. I switched endocrinologists afterwards, and he prescribed Fosamax after a brief discussion. I contacted the doctor who had prescribed Evenity, and he advised that I come to the office. He prescribed Tymlos, which I have now been on for 8 months. I changed my medical insurance to Medicare, and the doctor who prescribed both Evenity and Tymlos doesn't take it. I went back to the doctor who prescribed Fosamax after Evenity and he freaked out and said Tymlos is NEVER given after Evenity. His colleague in the same office concurred. He then ordered Prolia. I contacted the manufacturers of both Evenity and Tymlos, and they were very considerate and informed me that to their knowledge, there have been no studies about using Tymlos after Evenity. I am currently on a wait list for a new endocrinologist. I have a history of vertebral fractures and I need dental work, and I don't want to be on Prolia. I can finish the remaining months of Tymlos, or switch to Fosamax and wait and see what the new endocrinologist recommends. Needless to say, the situation is not ideal as I'm winging it. That being said, I know that treatment for osteoporosis is complicated and we patients have to be our own advocates and do a lot of research. I'm not opposed to that, but I'm not finding any information for protocols that have a progression of Evenity to Tymlos and then? If anyone has any information to share, I'd really appreciate it.

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Profile picture for hollygs @hollygs

@grammy9 I'm doing fine on it, I haven't had any discernible side effects whatsoever.

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@hollygs
Absolutely great news!!!

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I said no last year to Evenity. Doing great on TYmlos. I don’t have the numbers in front of me, but my PCP and Endocrinologist both very excited over the improvement on recent DEXA. Haven’t decided yet about Evenity for in the future. Leaning towards doing Raloxifene next, but this time around I’m now considering Evenity

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Profile picture for hollygs @hollygs

@grammy9 I'm doing fine on it, I haven't had any discernible side effects whatsoever.

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@hollygs
By “it” are you referring to evenity?

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Profile picture for daisylou @daisylou

I said no last year to Evenity. Doing great on TYmlos. I don’t have the numbers in front of me, but my PCP and Endocrinologist both very excited over the improvement on recent DEXA. Haven’t decided yet about Evenity for in the future. Leaning towards doing Raloxifene next, but this time around I’m now considering Evenity

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@daisylou
What was your baseline tscores and what were the last scan? I just started on Tymlos at 65 …my first osteoporosis drug.
My score was -4.8.

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Profile picture for osteopatient2026 @osteopatient2026

@hollygs
By “it” are you referring to evenity?

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@osteopatient2026 No, my answer was in response to @grammy9 who asked how I've been on Reclast.

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Profile picture for daisylou @daisylou

I said no last year to Evenity. Doing great on TYmlos. I don’t have the numbers in front of me, but my PCP and Endocrinologist both very excited over the improvement on recent DEXA. Haven’t decided yet about Evenity for in the future. Leaning towards doing Raloxifene next, but this time around I’m now considering Evenity

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@daisylou Do let us know what you decide and how your experience has been. Best wishes to you moving forward.

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What if any side effect did you have from Tymlos when you started? I’ve been on it 10 days woke up feeling a bit nauseous last night but it went away.
Have a little bit this afternoon but now I’m anxious

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Profile picture for osteopatient2026 @osteopatient2026

What if any side effect did you have from Tymlos when you started? I’ve been on it 10 days woke up feeling a bit nauseous last night but it went away.
Have a little bit this afternoon but now I’m anxious

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@osteopatient2026 I had no side effects from Tymlos in the beginning. Over time I felt some fatigue and joint pain. I hope you do well and best wishes to you moving forward!

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Profile picture for hollygs @hollygs

@osteopatient2026 I had no side effects from Tymlos in the beginning. Over time I felt some fatigue and joint pain. I hope you do well and best wishes to you moving forward!

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@hollygs
Did you have any nausea? Were you on calcium or any other supplements? Tymlos can put you into hyper calcium
Thx

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Profile picture for osteopatient2026 @osteopatient2026

@hollygs
Did you have any nausea? Were you on calcium or any other supplements? Tymlos can put you into hyper calcium
Thx

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@osteopatient2026 No, I didn't have any nausea and no hypercalcemia either. I was and still am on other supplements but my labs have been normal.

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