postop pathology to ChatGPT & asked about BCR. Anyone done this?.

I used ChatGPT for the first time and input my post-op pathology details into it and then asked about recurrence. To my surprise, it stated that for men with “several high-aggressiveness factors” like mine,I.e.,
* Seminal vesicle invasion (pT3b)
* Multiple positive surgical margins
* Cribriform + Intraductal carcinoma
* Gleason 4+3
* Decipher score 0.89 (high-risk)
I should consider “ultra early” radiation therapy. It went on to state that a Sustained detectible PSA as low as 0.03-0.05 ng/mL should be used as a threshold to initiate conversations with your oncologists about radiation early salvage treatment and possibly, ADT. It specifically said,
“ PSA 0.03–0.05 ng/mL and rising (confirmed on two tests)”

And emphasized,
“Do NOT wait until PSA reaches 0.1. Patients with these features progress quickly once microscopic recurrence begins, and outcomes are best when salvage radiation is given at very low PSA levels.”

Referencing the AUA/ASTRO/SUO 2024 Guideline:
* Recommends early salvage radiation when PSA first becomes detectable.
* Strongly favors PSA ≤0.2, but many experts recommend ≤0.1 or even ≤0.05 for high-risk patients.
*
2. Multiple large studies
Consistently show:
* Best long-term cancer control happens when salvage RT is delivered with PSA ≤0.05
* Outcomes are significantly worse once PSA rises above 0.1
* Waiting until 0.2 (the “traditional” definition of recurrence) is now considered too late for high-risk patients.

It went on to explain that while the broad consensus guidance still defines biochemical recurrence at PSA >=0.2 ng/mL, the studies this was based on did not include a statistically relevant number of higher risk patients or account for their specific tendency for greater metastasis velocity.

It certainly puts new emphasis for me on watching my PSA very very closely and I will be discussing with my doctors on the coming weeks depending on the outcome of my next PSA (blood draw on Tuesday 12/16/25).