Post prostatectomy: What do rising PSA levels mean?

Posted by hoard @hoard, Sep 10, 2019

New to group! Wish I had checked this out 2 years ago while supporting my husband! Now over e years post prostatectomy, wondering what might make psa go from all 0 to 2.6...

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@colleenyoung

As the discussion evolves to talk about hormone therapies and testosterone blocking, you may find the search function of the group useful to discover other discussions on the topic. For example, here are discussions related to:
- Orgovyx (relugolix) https://connect.mayoclinic.org/search/discussions/?search=orgovyx
- Finestride https://connect.mayoclinic.org/search/?search=Finestride

To find the Search for the prostate cancer support group:
1. Go to the Prostate Cancer support group page https://connect.mayoclinic.org/group/prostate-cancer/
2. Enter your search term in "search discussions"
3. Sort the search results by Discussions, Comments, etc.

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In my case it meant that cancer was left on the margin and remains where the urethra was connected to the bladder. I have been very fortunate in that it has taken 24 years to reach the point where I have started Orgovyx. I had a radical perineal prostatectomy in August 1999 with a preop PSA of 2.6. My PSA went to near zero (.05) after surgery. PSA started slowly rising and I was diagnosed with a recurrence in 2007. It was recommended that I have radiation to treat the recurrence. I had 35 treatments over 7 weeks and my PSA once again went to near zero. However, it once again starting rising, but very slowly, until it doubled in one year (Jan 2022-Feb 2023). My Mayo oncologist recommended that I start hormone therapy which I rejected. In March I moved to Rome, GA and engaged with the Harbin Cancer Center. I had consultations with a Medical Oncologist and a Radiation Oncologist> My PSA was then 3.62, higher than it had ever been. Bothe Oncologists said that if I did not do something to lower my PSA the cancer was certain to metastasize. That was a wake up call. I started on Orgovxy on September 6. I had my first follow-up visit this week and my PSA dropped from 3.62 to 0.42. My testosterone also dropped from 185 to 3, that of a 50> woman. The most bothersome side effect has been hot flashes that occur throughout the day. I hope this gives some insight when making decisions. I probably postponed starting hormone treatment longer than i should have.

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