Pluvicto success and PSMA test

Posted by cal77 @cal77, 4 hours ago

Hello,

Isn't the success rate of Pluvicto based on the PSMA test?
My husband had the PSMA scan and they said they would go ahead with pluvicto. He had the first treatment 5 weeks ago, it didn't work. His PSA has shot up from 800 to 1200!!!

The Oncologist said we should see results from the 2nd treatment which he gets next week. Here's hoping...

What if Pluvicto doesn't work...? He already had docetaxel and that didn't work either...

What a horrible disease prostate cancer is....

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

brianjarvis | @brianjarvis | 3 hours ago

What you’ll find in the data is that PSA levels can go up during Pluvicto treatment. Fluctuations and temporary spikes in PSA are quite common, especially during the first few cycles of therapy.

A temporary spike in PSA that occurs shortly after the first or second injection can happen. As the targeted radiation from Pluvicto successfully damages and kills the cancer cells, those dying cells rupture. This massive cellular breakdown releases a wave of stored PSA directly into the bloodstream.

This type of spike is actually a sign that the treatment is actively destroying the tumors.

If it were me, I would go for that 2nd (& 3, 4, 5,& 6) treatments.

If Pluvicto doesn’t work, you move on to next steps. (Was he PSMA-positive?)

Jeff Marchi | @jeffmarc | 3 hours ago

Sometimes you have to wait for the third treatment for the PSA to really start dropping, but it does not look promising. Pluvicto doesn’t work for everyone. You could try to get actinium. You may have to go to Europe to find a country that does it. I know someone who went to Austria.

Be aware that Pluvicto works really well for 33% of people OK for 33% of people and not at all for 33% of people.
If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant.