I have an advanced peripheral neuropathy with symptoms being far worse in my lower extremities. The neurologist and rheumatologist have said that the root cause of the neuropathy is Sjogren’s Syndrome and that is being treated with mycophoenolate with results pending as far as potential improvement of the neuropathy.
However, I also have stenosis issues and some doc compression in my cervical spine and my lower back and I am sure that an aggravation of either or both worsens the peripheral neuropathy. When you get into spinal issues a lot of voodoo emerges since the symptoms can be all over the place. In my case its clear that if I sit too long, especially driving, my lower back pain and stiffness will worsen and will peripheral neuropathy will worsen in conjunction. Conversely, if I walk too much, especially under load as in uphill, my cervical spine pain and stiffness will increase with impact to peripheral neuropathy less easily correlated.
So, the subject here is to link spinal issues and peripheral neuropathy symptoms and to be vigilant about how one affects the other.
As an aside, being overweight is, as usual, going to impact the spine by increasing the mechanical load. I’ve gained about 30 lbs in the last few years and that has made things worse in all domains. Very difficult to lose it.

https://en.wikipedia.org/wiki/Nerve_compression_syndrome

All input welcome, thoughts, observations, opinions…

Thanks