Parenteral Estrogen: an ADT alternative?

Posted by josgen @josgen, Nov 27, 2023

Here is a link where this question was examined:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052190/
Key points I learned:
-Oral estrogens were the treatment of choice for carcinoma of the prostate for over four decades, but were abandoned because of an excess of cardiovascular and thromboembolic toxicity (when estrogen was taken orally). This is NOT the case when estrogen is applied to the skin with patches and creams.
-Current conventional ADT is associated with considerable morbidity (castration syndrome/andropause) resulting in osteoporosis, hot flashes, cognitive dysfunction, asthenia (abnormal physical weakness or lack of energy) and anemia.
-Estrogen therapy is protective against the above side effects.
-Estrogen therapy is cheap.
-A side effect shared with some ADT drugs is gynecomastia. (Prostate cancer patients may receive radiation as a preventative measure to avoid gynecomastia. Radiation for this condition is generally given in very low doses with limited treatments. As a result, men experience minimal side effects, such as soreness around their nipples. )

One challenge to the patient wanting to utilize parenteral estrogen is that is use (today) would be off-label so getting the doctor and the insurance company on board is a crap-shoot. I may have to engage a naturopathic or function medicine practitioner for prescription guidance and I live close to Mexico so I can utilize a pharmacy there.

Here is a 1 1/2 hour video on the subject: The Role of Estrogen-Based Hormone Therapy for Treating Prostate Cancer
https://www.youtube.com/watch?v=S1CW9zfPe4Q

This is an intriguing option with positive Quality of Life implications!

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

I received the following message from a friend who is on estrogen therapy and was part of the study group - "The follow-up posting about dosing and the various forms of estradiol is not helpful as no prostate cancer patient should be taking oral estrogens given the blood clot risk of oral administration,"

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Agreed. The post IS NOT about using oral estrogen. It is about parenteral estrogen.

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