Pancreatic cancer recurrence: Anyone else?

My husband had half of pancreas and spleen removed with 20+ lymph nodes. They found cancer cells in 3 of the nodes when tested after surgery. He had received chemo pre and post the op. He was NED for a year. Christmas week his last scan and diagnostic laparoscopy showed cancer in the sac surrounding the organs mid body. Yesterday he began infusions of Gemcitabine and Abraxane. Currently there are no trials for him to participate in for his gene mutation KRAS G12D. We are hoping and praying that a trial of the inhibitors will be introduced for his gene mutation. He is now considered Stage IV and is in the palliative stage. He is not in any pain, but has neuropathy in hands and feet/legs. That was from
2 doses of Oxaliplatin in initial chemo last year. The doctor stopped giving it to him after the neuropathy started. We are hoping the two new drugs introduced to him this week will stop the cancer cells from growing.

@annsant
I too have KRAS G12D. Recently a visited a noted research center to find out about the recent work in this area. Also, I was on a zoom call with Dr Pant at MD Anderson today regarding vaccine trials for KRAS G12D
First let me say I just finished a round of gem/abraxane and it is making a difference for me in my tumor marker and also a “suspicious” area.
The vaccine is about to open phase 2 randomized trials. Not sure if your husband will qualify but worth a call!
Also I was informed that great progress is happening with G12D checkpoint inhibitors. So good that they may be available to the public in 2024!
If he has done 5FU/fulfurinox I think this cycle of drugs will be easier. Help him keep his attitude positive and keep up the good fight. We can turn this into a chronic disease soon!

PS look for KRAS Kickers on social media

My husband had half of pancreas and spleen removed with 20+ lymph nodes. They found cancer cells in 3 of the nodes when tested after surgery. He had received chemo pre and post the op. He was NED for a year. Christmas week his last scan and diagnostic laparoscopy showed cancer in the sac surrounding the organs mid body. Yesterday he began infusions of Gemcitabine and Abraxane. Currently there are no trials for him to participate in for his gene mutation KRAS G12D. We are hoping and praying that a trial of the inhibitors will be introduced for his gene mutation. He is now considered Stage IV and is in the palliative stage. He is not in any pain, but has neuropathy in hands and feet/legs. That was from
2 doses of Oxaliplatin in initial chemo last year. The doctor stopped giving it to him after the neuropathy started. We are hoping the two new drugs introduced to him this week will stop the cancer cells from growing.

I know the feeling of wanting to make sure that everything is done, at the same time I am cleaning out my house, I want to have enjoyment in my life. Have some more of winter left when I am not outdoors so much.

I know the feeling of wanting to make sure that everything is done, at the same time I am cleaning out my house, I want to have enjoyment in my life. Have some more of winter left when I am not outdoors so much.

Dear sadiegrace,
I love the tone of humility and grace in your response! You are very inspirational! I didn't have as much as a reprieve as you from pancreatic cancer; only 4.5 months. However, my dad who had it over 24 years ago was misdiagnosed (food poisoning!) and by the time he was properly diagnosed it was too late to do any treatment because it was literally in every organ of his body and lived for only 4 more months. He came to live us during his time of hospice (they are the most empathetic and kind group here) and they made life easier for all of us. Even though I only had 4.5 months of "cancer free", though it really never was the case as the scar tissue around my hepatic and celiac arteries that the radiologists and hence my drs called scar tissue, was actually soft tissue cancer that apparently appeared in the extra month of recovery due to complications from my surgery before I could begin my chemo; during that those 4.5 months I was elected to the Bolsa Chica Land Trust Board, and started my own little environmental consulting business where I worked part-time, and obtained a few state certifications related to water quality. I'm very thankful for those 4.5 months when I lived my life to the fullest in light of seeing my dad's withering state several years ago. I have a very aggressive cancer and am getting chemo again, but based on the genetics of my tumor, I don't have a lot of hope unless I can get into clinical trials and it works. My biggest concern is similar to yours, dotting i's and crossing t's so that my kids don't have to do much when that time comes and to make the transition as easy for them as possible and to get tested genetically. God bless you and you have my sincere admiration and prayers!

2020 diagnosed, chemo and radiation .February 2021 whipple, more standard chemo after whipple check 75 nodes ok. June 2021 became diabetic 1 and found spot, more chemo and radiation, of course continually chemo. 2022 start the hard chemo again. He has done exactly well for all his chemo -he started cramping before hard chemo and has never went away, he would be great if cramping would go away…supposedly his cancer isn’t growing or glowing not active just sitting for last 8 months: so don’t under stand the pain he hasn’t took chemo for 3 weeks and still doesn’t go away

How long did you have to take chemo on your reoccurrence?