Has anyone had a painful biopsy? What was the explanation?

Posted by warmer @warmer, Mar 21, 2025

Hi all--thank you for this warm and compassionate space for sharing experiences and encouragement. I have already learned a lot.
My question--if you have experienced a painful biopsy, did you ever get an explanation for the pain? And did you find anything that helped?
I have had three ultrasound-guided biopsies now for a cancerous tumor in my left breast. The tumor is attached to the chest wall. Several lymph nodes are affected, and the oncologist has assigned me to stage IIIb.
The first biopsy was just one core sample. It hurt like hell.
The second was a few core samples, and the placement of clips in the tumor and the lymph node. For this biopsy, I felt the pinch of the needle administering the lidocaine, but the actual procedure was not painful.
The third biopsy involved about 6 core samples (I have enrolled in a clinical trial that requires fresh samples and a mammaprint). One of the injections of the numbing agent stung quite a bit. And then the biopsy needle--my god. I think I might have scared the radiology team with my response-- gasping and crying! Eek! And yet--the last two core samples were just fine--some pressure, but very little pain.
Now, I do not want to alarm anyone who is heading into a biopsy procedure--I think the vast majority of patients have very little pain--just like my second treatment and some of my third! But I see that there are just a few people who report a more difficult biopsy.
If you had a painful biopsy, did you ever figure out what was going on?

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I had 3 biopsies and all three hurt very badly, especially when they placed the clip. I do believe it was a matter of how much lidocaine they gave because I also had to get an MrI guided biopsy and asked for stronger pain med which they gave. It didn't hurt as much as the stereotactic biopsies. Sorry you experienced pain also.

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The pain injection worked wonders and I felt no pain or very , very slight and very minor pain during biopsy.

I think it is best to request a netting with the hospital Pain Team if you are worried or concerned about pain. They will seriously address your concerns and advucate for pain medication.

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I understand your reaction to the “routine” biopsies used to diagnose BC. I also experienced extreme pain during all of my biopsies. I had multiple biopsies before my surgery to locate the tumor and place clips upon the exact location for pre surgery diagnostics. I have never had such intense pain. My left breast was literally black after the procedures. I also had seromas caused by each biopsy. My surgery was postponed while my surgeon waited for healing.
The entire process of those brutal biopsies is archaic, including multiple mammograms before and following surgery. I’m 3 years out now and refuse to have another mammogram (more radiation), and opt for ultrasound.
I have learned so much since my diagnoses in 2022. Breast cancer is Big Business, including standard protocols: multiple mammograms before and after, multiple diagnostic biopsies, expensive radiation treatments, meds including chemo, multiple doctor and nurse visits, scans and x rays for liver, kidney function and bone density. And on and on. Then the after meds prescribed for preventive care.
I had stage 1, early detection and surgery with post radiation (5 day, low dose). I have excellent insurance, so every possible treatment was indicated. Wow, I now know what cancer big business really is and feel that most of what I have gone through with the medical Standard Protocols is unnecessary and harmful. It is a runaway train for generating huge money, at the expense of the poor scared BC sufferers.

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When I needed a biopsy and had a woman surgeon, I underwent anesthesia. When I had a male surgeon it was tough it out. I think it's inexcusable.

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Same here—painful biopsy, etc. And then 17 different doctors. Lumpectomy, lymphnode ectomy-19, thirty sessions of radiation.
Gyno wanted to do hysterectomy because of cyst on ovary. Second opinion—“absolutely NOT!” I won’t do anymore MRIs, mamos, or ultrasounds. I’m done. Signatera, yes. Biopsy—only if you put me out! My five years with Anastrozole is up this August. Thirty side effects. I sooooo understand you girlfriend. Sending you love and lots of hugs! ❤️💕❤️I also had a knee replacement and hip replacement. Now I need a service dog for stability.

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Profile picture for jlam1950 @jlam1950

When I needed a biopsy and had a woman surgeon, I underwent anesthesia. When I had a male surgeon it was tough it out. I think it's inexcusable.

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@jlam1950
Absolutely, put us out or for a male surgeon—you go first.

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My MRI guided biopsy was the worst one I had. No lidocaine - I assume because they have no idea exactly where the needle will go in without the MRI. Robot did the needle - with me laying down & it reminded me of battleship for the robot. It also put a clip into my breast, it was very unpleasant. Turned out to be nothing and that was the only consolation I had from that. Good luck to all of you.

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