Other options available for Stage 4 Colon Cancer?

Yes I am starting Lonsurf and Avastin but I have come to see it as a tool that buys me more time to find a more sustainable (or curative) option. Unfortunately I am told I am not a candidate for typical hypnotherapy. (I am microsatalite stable)

As it stands, I am pursuing 2 other options:

1. The HAI pump idea that someone suggested. Although I had an oncologist tell me that since I had disease progression while on 5-FU that I probably wouldn't see great results with the pump because that's the drug they put inside it. That doesn't make sense to me because the pump should be around 400 times more powerful and directed... so I'd appreciate anyone's insights on that.

2. Clinical trial version of immunotherapy for people with NRAS mutation. But this seems extraordinarily difficult to search for since reading these clinical trials is like deciphering ancient greek. If this helps anyone else, I've been using these websites to search clinical trials: https://clinicaltrials.gov and https://www.mycancergenome.org

Lastly, thanks everyone for your responses and thanks Colleen for checking in. I appreciate the support and insights of this community. I will never stop fighting the good fight, no matter the odds. May God bless you all.

My husband has metastatic, stage IV colon cancer, after having survived 7 years from his initial 3b colon cancer that was treated w/ 12 rounds of Folfox tx. The cancer spread is in several places but his liver is by far the worst spot. Liver is inoperable. He was given two choices...hospice w/ 9 mo. to a year before a serious occurrence or 2 to 3 years of chemo for the remainder and/or David decides to stop tx.

With little hope they decided to give my husband a Hepatic Artery Infusion Implant. Operation went well and he started his Floxuradine tx a month or so later. He has only had 2 HAI's because his bilirubin and ALT levels are abnormal. This chemo is 300 to 400 times more powerful directly to his liver w/ few to no side effects, which David enjoyed. The idea is to shrink his liver masses, making it/them operable. David still gets his systemic tx through his port because he has tumors in a few other places and he is battling those as well.

We are taking a brief hiatus hoping that he can resume both chemo tx's at the same time. I'm hoping to see how others and their tx's are working for them.

In response to @stayfaithful, yesterday was my first consultation with the oncology team regarding the CT and MRI scans that they did.
Operating "could" be done, but since it is stage 4 (rectal tumor, liver, pancreas and other spots) surgery is not a good option. Surgery, as explained to me, would not be a "cure" whose benefits might be none or marginal - meaning that I would undergo a grueling and major disruption to my life with no promise of a benefit.
It sounds like your oncology team leader came to the same conclusion but without telling you so (or perhaps they did but you missed it under the avalanche of other information).

My onc team now want to biopsy the liver and pancreas to learn more about the cancers - the data will tell them which known therapies are most likely to be successful. Currently, the MRI/CT "shadows" on the liver and pancreas are mysterious but indicative of tumors.

So. . .it's into the machinery of modern healthcare I go. The unwanted adventure begins!

Yes, almost. Biopsy of the pancreas is adenocarcinoma - same as the rectal tumor. The liver could not be accessed through the stomach to obtain a needle biopsy although they do have ultrasound images of it.
Close enough to start chemotherapy.
This Wednesday I meet with the hematology doc to learn how screwed I am.
And Thursday they will install a port.
So. . .not long before the battle journey starts.

Yes, almost. Biopsy of the pancreas is adenocarcinoma - same as the rectal tumor. The liver could not be accessed through the stomach to obtain a needle biopsy although they do have ultrasound images of it.
Close enough to start chemotherapy.
This Wednesday I meet with the hematology doc to learn how screwed I am.
And Thursday they will install a port.
So. . .not long before the battle journey starts.

My husband is on Lonsurf, just starting the second series. So far he is stronger than on chemo. He has stage 4 colon and in both lungs. Hopefully this will slow the spread in his lungs

I am new to a stage four diagnosis. Had stage 3 in 2022 and twelve rounds of Folfox which we all thought was going to cure, but then metastasized to an ovary earlier this year. That ovary was removed so no current tumors. I'm at the point where every pain (I have a high threshold and rarely had pain before), is so frightening.