Estrogen blockers: Is there anything that helps with brain fog?

Posted by kbc123 @kbc123, Apr 1, 2025

Hi i.v been on oestrigen blockers for a few months now and they are causing brain fog . Is there any thing that could help this ?

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Profile picture for kathy913wi @kathy913wi

I recently 1/26/26 starting taking 20mg Tamoxifen. I seem to have a little trouble focusing and initially thought it was the combined events of downsizing, moving across country, lumpectomy in November, 5 treatments of radiation, the holidays, and accounting projects.

Wondering if anyone is taking supplements like B12 or Magnesium? Or other tricks.

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I’ve been taking Tamoxifen for over a year now- it took about 6 months for the moodiness and brain fog to improve. What helped- walking every day, get outside, yoga, getting quality sleep, infrared sauna with a cold shower after, eating nutritionally dense whole food and limited sugar, and seeking support/ counseling.

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Profile picture for kathy913wi @kathy913wi

I recently 1/26/26 starting taking 20mg Tamoxifen. I seem to have a little trouble focusing and initially thought it was the combined events of downsizing, moving across country, lumpectomy in November, 5 treatments of radiation, the holidays, and accounting projects.

Wondering if anyone is taking supplements like B12 or Magnesium? Or other tricks.

Jump to this post

@kathy913wi, I hope you saw the helpful posts you received from @triciaot and @mcallaham71. I moved your post to this related discussion so you can see more helpful tips:
- Estrogen blockers: Is there anything that helps with brain fog?https://connect.mayoclinic.org/discussion/oestrigen-blockers-brain-fog/

You might also be interested in this discussion:
- Cancer Related Brain Fog: How do you cope with it?https://connect.mayoclinic.org/discussion/cancer-related-brain-fog/

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Profile picture for Colleen Young, Connect Director @colleenyoung

@kathy913wi, I hope you saw the helpful posts you received from @triciaot and @mcallaham71. I moved your post to this related discussion so you can see more helpful tips:
- Estrogen blockers: Is there anything that helps with brain fog?https://connect.mayoclinic.org/discussion/oestrigen-blockers-brain-fog/

You might also be interested in this discussion:
- Cancer Related Brain Fog: How do you cope with it?https://connect.mayoclinic.org/discussion/cancer-related-brain-fog/

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Thank you so much!

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Regarding brain fog: I had it mildly with anastrozole. I switched to exemestane and it seemed to improve. It might be just a placebo effect, but I think it's worth trying a different aromatase inhibitor. Best wishes!

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Just read this new report on X …
@DrPatrick
&
@ImmunityBio
have just filed a patent for a new GLP-3 (aka similar to Retatrutide) that appears to cross the blood brain barrier (?) and treat BRAIN FOG and other neurological disorders! amazing!

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