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Newly diagnosed with Advanced PC

Posted by majark @majark, Aug 8, 2025

Well, maybe not newly. Back in Spring. Found in checkup and PSA tests. It was in places I wish it were not, and would be S4. I'm 68 year old male. I was put on ADT (Orgovyx and Nubeqa) which I have tolerated well for last 2 1/2 months and has good results re: knocking PSA #s way down. Next up, in another couple weeks will be an addition of 6 cycles of chemo to the ADT, specifically docetaxel. There is also possible clinical trial my oncologist is running that adds some radiation to that, but that would not start until a couple chemo cycles.
I've reached out to these boards 6 years ago when a family member was going thru a different type, and they were helpful. So here I am again, this time for me.
I'd like to get a second opinion from Mayo via telehealth, or a call. I did that several years ago, but don't recall procedure. I looked at website and wasn't sure of the link to use. Any help appreciated.
Lastly, for anyone who has gone thru this, I'm curious as to the docetaxel side effects. I've read all about them but wondering whether these are cumulative, and get worse in the cycles, or any other insight
Thanks

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majark | @majark | Aug 11, 2025
In reply to @stevecando54 "I'm stage 4, metastasized to the bones and a couple lymph nodes. About 18 months ago..." + (show)
Profile picture for stevecando54 @stevecando54

I'm stage 4, metastasized to the bones and a couple lymph nodes. About 18 months ago I finished up 10 rounds of chemo. I had good days and some not so good. Actually I had a problem with first two sessions, they changed up my prep and the rest were okay. It's almost a blur thinking about it now. Everything slowed down for me. The biggest so called problem for me was eating. Everything tasted bad, even drinking water. I want to say, you can do this. I continued to work at the time and my job kept me on my feet. Keep good attitude, stay positive and carry on. I wish you the best on your journey. Best to all.

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Thanks for the reply, Steve. Appreciate your experience. And your advising me on possible problems, especially eating. You've got the chemo in the rearview mirror for 18 months which is encouraging news. Best of luck going forward to you as well. I'm sure I'll be posting more as this goes on.

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majark | @majark | Aug 11, 2025
In reply to @florida11 "Good luck with the chemo. I just had 3 out of the 6 cycles. Taking Lupron..." + (show)
Profile picture for florida11 @florida11

Good luck with the chemo. I just had 3 out of the 6 cycles. Taking Lupron and Nubeqa as well. This may be off the beaten path too far, but for each cycle, I am doing the 5-day Prolon fasting mimicking diet (4 days before and the day of chemo), which is supposed to lessen chemo side effects and possible enhance results. Prolon was created by Dr. Valter Longo as a non-profit company. He also wrote the books The Longevity Diet and Fasting Cancer, which has a couple PC case studies in it. Check it out if interested. I have not had any mouth sores, feet or fingers issues, nausea, etc. My worst side effects were losing 85% of my hair, but I am grateful for what I have kept, and fatigue for about a week after each session. Although I think the fatigue is magnified a lot by the immune shots I take for 5 days after each infusion (I have low white blood cells and my insurance company would not pay for the single, more common shot).

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Thanks so much for your reply and info. Hadn't heard of the Dr Longo Prolon but will look into it. Hair loss doesn't especially trouble me, maybe it will when it happens. I was concerned about the mouth sores, neuropathy, other issues, so I'm happy those haven't really happened to you, and altho everyone's experience is different, hoping I have similar results. We'll see. After reviewing all who have been kind enough to jump on ere, I am sort of rearranging matters to give me a free week or so immediately after the treatments, then hope for some bounce back the next couple weeks before next treatment. Appreciate you and your insights

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lag | @lag | Aug 11, 2025
In reply to @majark "Thanks so much for sharing this story, quite helpful and am pleased that perhaps these good..." + (show)
Profile picture for majark @majark

Thanks so much for sharing this story, quite helpful and am pleased that perhaps these good times/bad times on side effects can be a bit predictable. Also, thanks for the heads up on the Neulasta and infusions. Will definitely keep an eye out on that. Appreciate your taking the time to reply, it helps a lot.

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You are very welcome. One thing that makes this predicament bearable is being able to give someone else the benefit of our experience. Hang in there and good luck!

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