new treatment option coming !?

And then there’s this one

Tiny silica particles wiped out aggressive prostate cancer in mice
https://www.sciencedaily.com/releases/2026/07/260708022158.htm
And another

Roswell Park Study: Inhibiting Regulator Protein Can Make Aggressive Prostate Cancers More Vulnerable.

BCL2 inhibitors in combination with a lutamide
https://physicianresources.roswellpark.org/news/roswell-park-study-inhibiting-regulator-protein-can-make-aggressive-prostate-cancers-more-vulnerable

@jeffmarc

Thanks !
The NW MO actually recommended the orgovyx and darolutamide as the 2 drugs husband would start with. Also said if a "tumor board would need to be convened, it would involve the NW Drs downtown." And that "all the Drs text each other all the time". It makes sense that they do. It's probably something like: "guess what walked into my office today! I got a Zebra! So excited to treat someone with such a dangerous, aggressive disease. Made my day". Pardon my sarcasm--its meant with lots of humor.

@dmx
Interesting that you found me and replied in a completely different set of messages.

I’ve had the same GU medical oncologist for the last eight years. We have never met in person, That really isn’t necessary. I’ve been meeting with every three or four months either video or telephone. She’s actually in the same city I’m in, But she was originally across the bay and there was no need to actually go see her since she had all my records.

You probably could connect up with that Northwestern oncologist I mentioned and not actually have to be physically there to have him directing your treatment.

You want to have a Genito Urinary Oncologist Working on your case, not just a medical oncologist. It could be that is what you’re working with but the ones that I mentioned are both GU oncologists. They specialize in prostate cancer and keep up with everything going on. Medical oncologist don’t specialize in anything usually and work with many different types of cases. That’s why getting the right doctor managing your case is important.

It could be you are working with the right doctor, but that’s why I brought it up originally And gave her the name of two really top-notch doctors to talk to.

It is good to hear that they are Recommending those drugs. I’ve had prostate cancer for 16 years, I’ve had Surgery and then radiation and it’s come back four times because I have the genetic problem of BRCA2. I’ve been on Orgovyx and Darolutamide For almost 3 years and it has kept me undetectable for the last 32 months. I’ve been on other drugs over the years that didn’t work as well.

You could request to have a second opinion with Dr. David J VanderWeele just to get him involved in the decision-making process.

Just some things to think about, You need to realize that prostate cancer is a chronic disease for almost all of us not a deadly disease.

WOW…that’s like the Holy Grail of oncology…an antibody that attacks cancer cells…
Thank you for the article and thank goodness for really smart people who never stop trying!
Phil

@jeffmarc Bizarre, right? Tiny silica molecules attack cancer…yet tiny silica particles attack healthy lung cells and cause silicosis and mesothelioma…🤷‍♂️

@heavyphil

Asbestos causes mesothelioma and there is difference between silica crystals and silica nano-particles. Completely different chemical structure. It is like comparing salt crystals to elemental Na. 😉

The work is very preliminary.

"Notably, the therapeutic effect was comparable to that of docetaxel, a current standard-of-care chemotherapy, without noticeable side effects on body weight, proximal aorta or heart function detected"....

"in immune-deficient mice".

This is research conducted in Sweden.

Check this article describing what is happening to US research, i.e. NIH funding https://pmc.ncbi.nlm.nih.gov/articles/PMC12322968/

From the article: "Many of us in oncology are concerned about federal funding cuts that may continue to negatively impact cancer research, leading to reductions at the NCI and the NIH, a lack of psychosocial support services, and increased overall health-care costs. Funding cuts will ultimately limit access to health-care services for underserved and diverse populations and lead to increased rates of burnout due to understaffed practices in hospitals and clinics across the nation. Advanced practitioners comprise a large group with the ability to advocate for our patients and profession.

I urge you to partner with your hospitals, government groups, and professional societies such as APSHO, the American Society of Clinical Oncology, and the American Society of Hematology to advocate for funding support for research."

@surftohealth88 Yes, right you are…every time I see anything with ‘silica’ in it I immediately think of my father who died from mesothelioma caused by asbestos in the shipyards…
Co-workers also got the disease and some got silicosis - not 100% fatal, but not good either. Thanks,
Phil

I saw the one Jeff mentioned with the silica but not this one. Thx for posting. What is encouraging is that they are exploring completly different biological pathways.