New to the stage 4 colon cancer world

My wife just discovered a small spot on her liver that came from her colon cancer that was removed a year ago, which at the time was not found in her lymph nodes. She is really struggling with the idea of folfox chemo, as suggested by her current oncologist. We are scheduled for a secondary opinion at mayo in a week. Prior to that we are doing all kinds of research of methods to really attack side effects of the chemo, looking at low dose chemo treatments, and embracing more integrative compliments, like diets, and supplements that can make chemo easier, less toxic and or more effective. Does anyone have thoughts or referrals on these topics? Our current oncologist (not mayo) has more of a just do it attitude on chemo, does discuss the rest of how to treat life differently and my wife really embraces the body's own immune system. Hopefully this makes sense - any advice/recommendations are appreciated.