New device: A neuroinfusion drug delivery system for brain tumor chemo

Posted by marcyprof @marcyprof, Nov 28, 2019

Hope when we want… Have you heard about a new drug infusion device that is being treated directly in the brain? This has been developed for Parkinson’s, but it can be used to make brain tumor chemotherapy in situ rather than to poison the whole body. Here is the device link: https://www.renishaw.com/en/neuroinfuse-drug-delivery-system–42358

Hi, @marcyprof – sounds like an interesting concept. Connect members like @pejiota4jack @dianeem @IndianaScott @eileen61 may be interested in this infusion device for direct treatment of the brain.

I think that the link you included in your post may have changed, as it's now going to a "page not found" message. If you have the updated link, others may be interested to take a look at it.

You've mentioned in other threads, marcyprof, that you have a non-operable brain tumor. Is this type of drug infusion something that your doctor thinks might be a possibility for your treatment?

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Hi, @lisalucier – The Internet address is always good, from here (Canada) right now (I just tried it). Maybe you can do a search on Google with the words: renishaw neuroinfuse drug device.
Regarding my brain tumor, I regularly receive intra-arterial chemotherapy (carotid). This Renishaw device would be able to transport the poison-chemo directly into the tumor rather than all the body's blood. I will discuss it with my neurosurgeon and I will give you news.

Liked by Lisa Lucier

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@marcyprof

Hi, @lisalucier – The Internet address is always good, from here (Canada) right now (I just tried it). Maybe you can do a search on Google with the words: renishaw neuroinfuse drug device.
Regarding my brain tumor, I regularly receive intra-arterial chemotherapy (carotid). This Renishaw device would be able to transport the poison-chemo directly into the tumor rather than all the body's blood. I will discuss it with my neurosurgeon and I will give you news.

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Hi, @marcyprof – did you end up doing treatment with the neuroinfusion drug device? If so, how did it go? This was for glioblastoma, correct?

I also thought that @kate4damian @ginette55 @sarasally2 @debraannk and @becsbuddy might be interested in your response.

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I met with surgeons at Duke this week and I think we are going with stereotactic radiosurgery, anyone done this procedure?

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@lisalucier

Hi, @marcyprof – did you end up doing treatment with the neuroinfusion drug device? If so, how did it go? This was for glioblastoma, correct?

I also thought that @kate4damian @ginette55 @sarasally2 @debraannk and @becsbuddy might be interested in your response.

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Hello @lisalucier, I discussed this device with my neurosurgeon, a researcher-expert in the field of GBM. He told me that this device does not meet the needs precisely because it pours the poison-chemo locally while brain tumors are known to be infiltrative (arborescent). He therefore prefers intra-arterial chemotherapy, which is scattered in all blood vessels.
I was a little disappointed because the chemo poisons my whole body (and not just my tumor). This is also the reason why, after 14 treatments over 15 months, we have just stopped this medicine. In the coming months, we will see if my tumor, which is atypical, does not remain stable by itself.
So, according to my doctor, this technique would not be suitable for GBM multiform. But perhaps other neurologists would see an interest in it?

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@marcyprof

Hello @lisalucier, I discussed this device with my neurosurgeon, a researcher-expert in the field of GBM. He told me that this device does not meet the needs precisely because it pours the poison-chemo locally while brain tumors are known to be infiltrative (arborescent). He therefore prefers intra-arterial chemotherapy, which is scattered in all blood vessels.
I was a little disappointed because the chemo poisons my whole body (and not just my tumor). This is also the reason why, after 14 treatments over 15 months, we have just stopped this medicine. In the coming months, we will see if my tumor, which is atypical, does not remain stable by itself.
So, according to my doctor, this technique would not be suitable for GBM multiform. But perhaps other neurologists would see an interest in it?

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@marcyprof This sounds like such a novel way to give chemo for brain tumors! When I was working, patients were coming in for placement of an omaya reservoir. It directly accessed the cerebral spinal fluid while bypassing the blood-brain barrier.

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Can you give more explanation? my grandson has a brain tumor. He is 14 years old. They gave up on him.

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Good morning @ginette55
I’m not sure if you were talking to me, but here is some info. I’m not even sure if ommaya reservoirs are still used as they keep finding newer and better ways of doing things.
https://www.princetonneurologicalsurgery.com/our-services/brain-surgery/ommaya-reservoir-placement/
I’ll keep you and your grandson in my heart.

Liked by Lisa Lucier

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Thank you. There are side effects. I will let my daughter know about it. THANK YOU .

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Interesting! Thanks

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@ginette55

Can you give more explanation? my grandson has a brain tumor. He is 14 years old. They gave up on him.

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Hi, @ginette55 – just to clarify, do you mean your grandson's doctors gave up on treating his brain tumor?

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@becsbuddy

Good morning @ginette55
I’m not sure if you were talking to me, but here is some info. I’m not even sure if ommaya reservoirs are still used as they keep finding newer and better ways of doing things.
https://www.princetonneurologicalsurgery.com/our-services/brain-surgery/ommaya-reservoir-placement/
I’ll keep you and your grandson in my heart.

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You're right Becky@becsbuddy, the advantage of Ommaya's reservoir is that it sends the drug directly to the tumor. There are therefore fewer negative side effects of chemotherapy on the patient.
I discussed this with my neurosurgeon who has already installed some of his patients. He explained to me that this technology is effective depending on the location of the tumor. In my case, because the tumor is located near the 3rd ventricle, this is not an option but it would seem that it is a proven biotechnology for GBM.

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