Zoledronic Acid: I need feed back for this drug please

I take Reclast every three months and am doing well with it now, but did not at first. I had a serious allergic reaction. My arms, legs and feet, face and neck were bright red and stinging. A steroid pack alleviated the problem, but I still need the drug to offset the bone-loss effects of ribociclib and furvescent and to build protection against bone mets. I could not tolerate Prolia. I now receive an antihistamine and steroids in my30-minute infusion and have no problems with it. I also make frequent check-up visits to my dentist and exercise a lot. Wish taking care of me didn't take so much time, but I'm thankful there is help!

Believe it or not, this forum is what I found for Zoledronic Acid infusion patients. I am male, cancer patient; hormonal treatment (Luperon infusion) has caused or contributed to osteoporosis. Oncologist wants me to do Zoledronic Acid infusion; I am reticent to do so as the more gruesome side effects scare the dickens out of me, especially as the drug persists for up to 2 years. I have noticed that the comments and questions in this forum are not from patients who are or have experienced any of the serious side effects (the expected flu symptoms prevail). Is there anyone out there who is or has experienced the more serious side effects, treatment for those side effects, duration, etc.? I must very shortly make decision. Thanks.

@fidelisgwc I also have osteoporosis due to hormone meds to treat my breast cancer. The osteoporosis was first discovered this last fall. My oncologist wanted me to go on Zolendronic Acid infusions once every 6 months for 3 years. I was also very reticent after reading about all the possible side effects. I told her that I would be very careful not to break a bone; holding on to railings and not walking on ice. She informed me that all it would take is stepping off a curb or turning my ankle when I walked to break a bone. It doesn't matter how careful you are. She went on to say that my hormone meds are the heavy hitters in my cancer fight, even more so than the chemo and radiation were. If I don't want to treat the side effects of the hormone meds (osteoporosis) then they don't feel like they can, in good conscience, keep prescribing the hormone meds and my cancer could return. I felt like I was between a rock and a hard place, so I finally agreed to the Zolendronic Acid (Zometa) infusions. I had my first infusion in November 2025. Other than an achy feeling and a low-grade fever for about a week after the infusion, I have had no other side effects that I can pinpoint to the Zolendronic Acid infusion. My eyesight is a little worse, but that just could be my age (71). I am concerned about my teeth loosening, but so far there has been no change in that. I hope and pray that I will not have any additional side effects. I've read that with each infusion, as your body adapts, there will be fewer body aches and fevers. Good luck with this. It is a difficult decision.