MGUS progression and excess weight

Posted by wesleym @wesleym, Feb 10 11:07am

During the six months or so that I've been reading and occasionally contributing to these conversations, I've seen numerous threads relating to slowing MGUS progression by means of various diets or supplements. Although there are a few ongoing clinical trials, the evidence for those things is equivocal. For one factor, however, the evidence is strong: excess weight, especially following MGUS diagnosis, increases the likelihood of progression to MM. I was diagnosed with high-risk MGUS about ten months ago, and am teetering on the treatment / no treatment edge, so this is of considerable interest. Reference:
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2830028

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msh466 | @msh466 | Feb 10 2:19pm

Reading these threads always provides greater awareness of the science and studies that are currently ongoing. So much data that the only way to keep up is to read it here. I have never heard that BMI could influence MAGUS to MM. This is great info to know. Thanks

kayabbott | @kayabbott | Feb 11 8:55am

In reply to @msh466 "Reading these threads always provides greater awareness of the science and studies that are currently ongoing...." + (show)

Excess weight increases the risk of a number of different cancers. Is your MAGUS the same as MGUS or is it a variant?

kayabbott | @kayabbott | Feb 11 9:02am

There may be clinical trials for high-risk MGUS, and more likely if someone has bone lesions, kidney disease, or other manifestations, but in general MGUS is a wait-and-see condition. I have had IgA Kappa MGUS for 8 years and some risk (1q21 gain) of progression, but my kappa and other numbers ramp up and down. I do take about 3 gm of bioavailable curcumin a day, just in case that has any effect on TNF (tumor necrosis factor), diet, enough sleep, exercise, destress, and try to have fun. One of the reasons that MGUS is wait and see is that the meds and BMT can have some side effects, and it may not progress to MM.

anjill22 | @anjill22 | Feb 11 12:17pm

In reply to @kayabbott "Excess weight increases the risk of a number of different cancers. Is your MAGUS the same..." + (show)

What is MAGUS?

wesleym | @wesleym | Feb 11 12:56pm

In reply to @anjill22 "What is MAGUS?" + (show)

> What is MAGUS?

SORCEROR. Medically, I don't know. MGUS?

wesleym | @wesleym | Feb 11 1:08pm

There are definitely clinical trials, both ongoing and recruiting, concerning various aspects of MGUS. See https://clinicaltrials.gov/search?cond=MGUS Particularly interesting for me is an ongoing trial of the efficacy of daratumumab in delaying progression of high-risk MGUS and SMM. https://clinicaltrials.gov/study/NCT03236428 However, that study is only Phase II, meaning that even if it finds delay in progression, it does not show ultimate benefit.

kayabbott | @kayabbott | Feb 11 5:01pm

Regarding MAGUS, a person on this string of comments has posted a few times about "MAGUS" and I was curious as to whether this is something different than MGUS. Perhaps a spell check issue.

Patty, Volunteer Mentor | @pmm | Feb 12 4:34pm

@kayabbott I assumed it was a spellcheck issue. I'm happy to have spellcheck assist me if my fat fingers produce a typo, but I don't like it when it changes my intended words.
I am fluent in typo.

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