MGUS FLC Ratio decreasing

Posted by hpatel334 @hpatel334, Jan 11, 2024

I am 25 M, and I diagnosed with IGG Lambda MGUS 2 years ago. My protein when diagnosed was 0.4, but now it measures 0.7. It has gone to 0.6 in a year and is now 0.7. My FLC ratio was 0.48, but now is 0.27, at the cusp of out of range. It has always been decreasing since diagnosed but it scares me. Because of my age, my hematologist has put me on a 4-6 month check for now. I even got a BMB last July and it confirmed 3.4% plasma cells involvement, showing MGUS. How much does the ratio fluctuate? I know one chain increasing is not ideal, but it is whats happening and I cannot control it. I am vegeterian, try to not eat junk food and regular exercise. Has anything helped to stay stable?

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kayabbott | @kayabbott | Jan 12, 2024

I'm 69 F with kappa light chain MGUS. My kappa/lambda ratio (7.76) has been slowly ramping up over the 8 years since diagnosis. Tumeric (curcumin) with black pepper (increases curcumin absorption) helps with tumor suppression in lab tests; don't know if it works with us, but I eat a lot of tumeric (good in curries, stews, hot chocolate). Tumeric is cheaper in Indian markets. I keep a food log (started with celiac 14 years ago) to see if any things hit me (gluten, some legumes and processed foods, and NSAIDs) through bloating, fatigue, or other symptoms. I'm also low sugar and no artificial sweeteners. Excessive weight gain is an issue with various diseases, so I keep my weight down and exercise a lot. Only a small percentage of MGUS progresses to cancer and hopefully ours doesn't, but just having it is stressful. Being vegetarian and minimising junk food is good. Make sure you get enough Omega 3 fatty acids. Escaping mentally is important, doing fun things and avoiding stress. MGUS unfortunately is something we have to live with, hopefully for decades. There are a number of MGUS peer reviewed papers in ResearchGate; they are written to scientists so the terminology can be tricky. I'm a scientist, maybe why my post is written like a geek or obsessive person.

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