Does anyone else have MGUS?

My MGUS was found through routine blood work (August 2022) Quest Lab suggested 2 more tests be done. Those produced the MGUS IgG results.
Prior to that I had high calcium (now diagnosed with hypercalcemia) and I have had numbness, tingling from my ankles down to my feet for some time prior to MGUS diagnosis. Very annoying. Otherwise, doing well, walk 2-3 miles every morning with neighbor.
@gingerw has been very helpful with her comments.

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Hi @sissypuss Welcome to Mayo Connect. It can be pretty startling when we discover something on our charts and have no idea what it means.
MGUS~Monoclonal gammopathy of undetermined significance (MGUS) is a blood disorder that affects plasma cells in your bone marrow.
People can have this slowly developing condition for years without any symptoms. It’s usually found on a routine physical with blood work.

We have a number of members in this support group who also have MGUS and there are quite a few discussions besides this particular conversation. You can find those by simply typing MGUS in the search bar above. That will provide a listing of the different subjects associated with MGUS.
Since you’re new to the diagnosis, it can be helpful to read about your condition. To get you started I’ve posted 3 excellent sources so that you can learn more about MGUS.
https://www.healthline.com/health/how-serious-is-mgus
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https://www.mayoclinic.org/diseases-conditions/mgus/symptoms-causes/syc-20352362
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https://my.clevelandclinic.org/health/diseases/17744-monoclonal-gammopathy-of-undetermined-significance-mgus
If you found comment on your patient portal, was this through routine blood work with a primary care physician? If so, they should be following up with you for a referral to a hematologist( a blood specialist). Was this a recent test? Were you having any symptoms weakness, tingling or numbness?

You need to see a hematologist

There are definitely links between MGUS and neuropathy. I have had MGUS for 3 years and neuropathy for about a year. About 20% of people with MGUS develop neuropathy.

I was diagnosed with MGUS 23 years ago. My numbers have remained stable for all these years. Since there’s no treatment for it, I wouldn’t worry. Just have your bloodwork done every 6 to 12 months. I’ve put it aside mentally If you have symptoms see your Hematologist. Severe pain and fatigue would be what you would be looking for. I hope you are like me and it just becomes something to watch and nothing more. Best health

Hi Leslie,
They scanned my bones last year and found lesions that turned out to be osteopenia. I’m not on any medication for it though, except increased calcium supplements. The only reason they did the bone scan was because I had lost a lot of weight without trying. That turned out to be because of another illness called exocrine pancreatic insufficiency. My next oncology appointment is in July, and I’ll be curious to hear what the results are this year. Best of luck to you!

I also go yearly for bloodwork. I’ve found that exercise is essential to feel my best.

Hi Susan:
I was diagnosed about 2 years ago with MGUS from routine physical- trying to explore causes of osteoporosis- also newly discovered. I’m also 64, and thought I was healthy.
I’ve taken some powerful osteoporosis medication and trying to determine if that’s why I have more fatigued or if it’s from the MGUS?
MGUS supposedly is asymptomatic but I wonder.
Thought I’d reach out.
I’m supposed to be a little above average risk but who knows about these statistics,right?
Wishing you good health- encouraging to hear you’ve been stable for 10-15 years.

I’ve had it for somewhere between 10-15 years. I see a hematologist and oncologist once a year while the numbers have increased steadily, I am not at the smoldering level yet, and my oncologist says I have only a 10% chance each year of developing multiple myeloma. I’m 64.