Does anyone else have MGUS?

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Slowly rising, 284 lambda now k/l quotient 0.04 now!
Still waiting thank goodness

Thank you! I’m hoping that’s the case too.
Immunology is fascinating and research goes so fast now- hoping we learn more soon about inflammation and autoimmunity.
The cytokine storm is what killed so many people with Covid infections. Once our immune system is ramped up, it can become its own worst enemy.
Lots still unknown - clearly the vaccine helped much more than it caused harm.

Fingers (and toes) crossed that you don't have MGUS and instead something that is leaving. There is so much to learn. I have celiac because of H1N1 followed by high stress (and genetics). I got glutened last March the same day I was exposed to covid. Having covid during a cytokine storm was not fun. My long covid (LC) is almost gone. Vaccines do trigger our immune systems, and are they still on alert once the mRNA bits are gone? There are similarities between LC and some autoimmune diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253807/#:~:text=In%20conclusion%2C%20abnormal%20levels%20of,prognostic%20biomarkers%20of%20selected%20diseases.
* Last one:
General study of elevated FLCs and autoimmune and inflammatory type disorders.

Maybe the anti inflammatory supplements (curcumin, cherry tart extract, omega 3s) I’ve been taking have helped me?
I just want to be as healthy as possible and have an open mind.
✌🏻

https://iris.uniroma1.it/retrieve/e383532d-0a89-15e8-e053-a505fe0a3de9/Farina_Transient-plasma_2021.pdf
This is an Italian study - again shows a monoclonal gammopathy found unexpectedly in Covid patients and tries to explain what might be causing this.

* I didn’t get an covid infection before the MGUS was found, just the vaccines. When I did, it was mild and caused no lasting effects.

https://www.mdpi.com/2075-1729/13/3/734
This was a stable patient who had MGRS and relapsed after getting her 2nd Moderna vaccine- resulting in an acute worsening kidney disease and hemodialysis for the rest of her life.

I look at these as smoking guns- not proof- but worthy of exploring further.

“Monoclonal gammopathy results from clonal proliferation of plasma cells or antibody secreting B-cells, producing large amounts of homogenous immunoglobulin or light chain fragments. An “acute” or transitory monoclonal spike has been reported in association with a spectrum of acute and chronic inflammatory illnesses, including viral infections.“
https://www.htct.com.br/en-acute-monoclonal-gammopathy-in-severe-articulo
S253113792030064X

* This pertains to an M spike found in 2 older patients who actually had a severe Covid infection.

Stay tuned for more…😄

Thank you kayabbot - I’m also from a medical background and found those studies you cited and know how research works. I appreciate the explanation though.
I have inferred the connection between the mRNA vaccines I took and the changes in my health - it’s only a theory and time will tell.
Or I’ll never know? My MM doc said we’ll know in 20-30 years if there’s a connection. I got the feeling he’s been asked that before!
As I said, I think the vaccines overwhelmingly worked to save many lives- only just a few who may have had changes in their immune system beyond the expected Covid immunity.

I will look for the studies that led me to start thinking that there might be causation and post here.
My own condition is now being explained as possibly not MGUS or something similar that could be resolving.

I looked for the covid vaccine triggering plasma cell dycrasias @leslie2121 and @kappaking and found a number of research papers on effects of covid vaccine on people that ALREADY have dyscrasias. Also, if a publication has "may" it means it is not a conclusion, more a possibility (I'm a research scientist and have also reviewed a lot of papers). Vaccines are designed to ramp up your immune system so it can be vigilant for invaders. Our personal home security system. Could autoimmune diseases be triggered by some vaccines in genetically or otherwise susceptible people? Time and research will tell so it is important to keep searching for information. Autoimmune diseases can potentially be triggered by a number of things, Reactive Arthritis by chlamydia, Lyme disease from bacteria, viruses, pregnancy, and other stressors. Here is one on the covid vaccine NOT impacting MGUS: https://ashpublications.org/blood/article/140/Supplement%201/261/487616/Sars-Cov-2-Vaccinations-Do-Not-Lead-to-Progression This "online library" paper is not research, it is more a pondering, looking at common effects on the body of covid and other diseases/conditions. Perhaps that is the link between covid and afflictions that you were referring to? There is no controlled study, just suggestions, which are fine but need actual research to see if there real links. https://onlinelibrary.wiley.com/doi/10.1002/iid3.701 . Starting with the Obama administration all Fed. govt funded research papers have to be available to the public within a year of publication; the upside of that is there is a lot of great medical and other info out there. Downsides are they are mostly written in to scientists so not as easy for the public to read, analyze, or interpret them.