Does anyone else have MGUS?

Posted by mjlandin @mjlandin, Jun 4, 2022

I was diagnosed with MGUS last October and although I've done a lot of research, I feel there's still so much I don't know. Does anyone else have MGUS?

Interested in more discussions like this? Go to the Blood Cancers & Disorders Support Group.

kbluegrass | @kbluegrass | Mar 17 1:03pm

In reply to @mascot "Slowly rising, 284 lambda now k/l quotient 0.04 now! Still waiting thank goodness" + (show)

I am glad it is moving slowly.

kbluegrass | @kbluegrass | Mar 17 1:01pm

In reply to @leslie2121 "Looks like they found the TP 53 mutation in only 9% of the cells. I don’t..." + (show)

Thanks Leslie! Appreciate your feedback. Amazing really that 9% of a type of cell being mutated is small, but I'll take it as a positive! 🙂

Kappa King | @kappaking | Mar 17 12:41pm

In reply to @leslie2121 "“Monoclonal gammopathy results from clonal proliferation of plasma cells or antibody secreting B-cells, producing large amounts..." + (show)

< deleted>

mascot | @mascot | Mar 17 9:54am

In reply to @mascot "A lot more(250) lambda, 20%in bone marrow and the checkup is next week so will find..." + (show)

Slowly rising, 284 lambda now k/l quotient 0.04 now!
Still waiting thank goodness

2121 | @leslie2121 | Mar 17 9:44am

In reply to @kayabbott "Fingers (and toes) crossed that you don't have MGUS and instead something that is leaving. There..." + (show)

Thank you! I’m hoping that’s the case too.
Immunology is fascinating and research goes so fast now- hoping we learn more soon about inflammation and autoimmunity.
The cytokine storm is what killed so many people with Covid infections. Once our immune system is ramped up, it can become its own worst enemy.
Lots still unknown - clearly the vaccine helped much more than it caused harm.

kayabbott | @kayabbott | Mar 17 9:31am

In reply to @leslie2121 "Thank you kayabbot - I’m also from a medical background and found those studies you cited..." + (show)

Fingers (and toes) crossed that you don't have MGUS and instead something that is leaving. There is so much to learn. I have celiac because of H1N1 followed by high stress (and genetics). I got glutened last March the same day I was exposed to covid. Having covid during a cytokine storm was not fun. My long covid (LC) is almost gone. Vaccines do trigger our immune systems, and are they still on alert once the mRNA bits are gone? There are similarities between LC and some autoimmune diseases.

2121 | @leslie2121 | Mar 17 9:24am

In reply to @leslie2121 "https://iris.uniroma1.it/retrieve/e383532d-0a89-15e8-e053-a505fe0a3de9/Farina_Transient-plasma_2021.pdf This is an Italian study - again shows a monoclonal gammopathy found unexpectedly in Covid..." + (show)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253807/#:~:text=In%20conclusion%2C%20abnormal%20levels%20of,prognostic%20biomarkers%20of%20selected%20diseases.

* Last one:
General study of elevated FLCs and autoimmune and inflammatory type disorders.

Maybe the anti inflammatory supplements (curcumin, cherry tart extract, omega 3s) I’ve been taking have helped me?
I just want to be as healthy as possible and have an open mind.
✌🏻

2121 | @leslie2121 | Mar 17 9:13am

https://iris.uniroma1.it/retrieve/e383532d-0a89-15e8-e053-a505fe0a3de9/Farina_Transient-plasma_2021.pdf

This is an Italian study - again shows a monoclonal gammopathy found unexpectedly in Covid patients and tries to explain what might be causing this.

* I didn’t get an covid infection before the MGUS was found, just the vaccines. When I did, it was mild and caused no lasting effects.

2121 | @leslie2121 | Mar 17 8:58am

In reply to @leslie2121 "“Monoclonal gammopathy results from clonal proliferation of plasma cells or antibody secreting B-cells, producing large amounts..." + (show)

https://www.mdpi.com/2075-1729/13/3/734

This was a stable patient who had MGRS and relapsed after getting her 2nd Moderna vaccine- resulting in an acute worsening kidney disease and hemodialysis for the rest of her life.

I look at these as smoking guns- not proof- but worthy of exploring further.

2121 | @leslie2121 | Mar 17 8:52am

“Monoclonal gammopathy results from clonal proliferation of plasma cells or antibody secreting B-cells, producing large amounts of homogenous immunoglobulin or light chain fragments. An “acute” or transitory monoclonal spike has been reported in association with a spectrum of acute and chronic inflammatory illnesses, including viral infections.“
https://www.htct.com.br/en-acute-monoclonal-gammopathy-in-severe-articulo
S253113792030064X

* This pertains to an M spike found in 2 older patients who actually had a severe Covid infection.

Stay tuned for more…😄