MGUS and quite high Free Kappa Light Chain and Kappa Lambda Ratio

I didn't want to know much about my MGUS results although I was getting tested every 4 to 6 months for the first 2 years. (I guess life with the pandemic was enough for me!
Anyway, now I would like to understand my results that show:
1. IgG with Lambda Light Chain with Faint Bands"
2. High free Kappa Light Chain
3. High free Kappa Light Chain ratio
(Fortunately, the M Spike that I had appeared once last year is no longer appearing).
If anyone can explain these further or offer links to other references, I would be most appreciative. Thank you!

I have IgA lambda MGUS. Has anyone been able to find out anything about it? I see a hematologist at Northwestern Memorial in Chicago, and luckily I don't need any treatment, but the cloning level keeps rising every time I'm tested. The only thing I've seen about IgA is that it has a less positive prognosis than IgG. But that's it; nothing more about it. Anyway, I just want the cloning to stop. Does anyone else have this type of MGUS? If so, please let me know what's going with you. Thanks.

I have IgA lambda MGUS. Has anyone been able to find out anything about it? I see a hematologist at Northwestern Memorial in Chicago, and luckily I don't need any treatment, but the cloning level keeps rising every time I'm tested. The only thing I've seen about IgA is that it has a less positive prognosis than IgG. But that's it; nothing more about it. Anyway, I just want the cloning to stop. Does anyone else have this type of MGUS? If so, please let me know what's going with you. Thanks.

Becky I have a MGUS diagnosis and have been to a hemotologist to test for MM. My M(IgM is 349. I saw yours was at 326. I have IgM Kappa type. It's all new to me. I've been doing a lot of research but won't know until March 31st when I see the results from my doc what all this means.

Greetings from Arkansas. I SO relate to the anxiety of getting fragmented information when they first discover blood abnormalities. I literally made myself sick worrying. Dr Google is not your friend. The more I read, the more panicked I got which is really not my jam! I’m used to being a calm voice in the storm, not the cyclone.
I have MGUS and was diagnosed almost two years ago now. We are watching but I try not to think about it as waiting. My MGUS may never progress. And I’m the unlikely event that it does, the treatment for Multiple Myeloma is much improved, according to my hematologist/oncologist.
I get bloodwork every three months. I get a CT scan annually that checks me head to toe for lesions. I live my life.
What worked for me was first finding a physician who is experienced in treating Multiple Myeloma. I wanted a specialist…hematologist/oncologist. Don’t let the oncologist part scare you. MGUS is not cancer.
Then you have to trust the process. Educate yourself about what they see in your blood that is giving them pause and how they will monitor your health. Do this by asking questions. Write them down. My initial appointment with my hem/onc doc was over an hour long. He was a trooper.
I never look at my lab results until I am sitting in the office with him. Others do it differently, but I think “My Chart” is the devil’s invention when it comes to this highly complex blood analysis. No good ever comes from heightened anxiety, especially when the source of your anxiety may be nothing to worry about.
Good luck! Glad you found our little community. Please update us as you travel this path. You are not alone.
Patty

that sounds like a plan, I am always googling and my doctor says dont google but i just want answers like yesterday!!!

I’ve been battling MGUS since May 2019 ever since I realized something was wrong with my bloodwork and asked my PCP to do specialized testing. That’s when my testing and troubles began. The wait and watch testing is standard for MGUS. The 24hr urine test is also an important tool in determining how things may be changing. The urine testing is done to check if you are passing the “M paraprotein”.

It looks for an M Spike, an indication that the paraprotein is progressing (not good) and you cells are headed towards a form of cancer, usually Multiple Myeloma or Lymphoma (mine indicates Lymphoma), my older brother’s was MM and died in 1999,. The number to be concerned about is 0.5 gd/L. Above that indicates your MGUS is progressing towards cancer of some kind. My last bloodwork shows my M/Spike was at 0.56 gd/L (not good). It means my bad guys are on the move and mutating. I pretty much figured that out because of all the new symptoms popping up all around my body.

Now for your Kappa, Lambda question. It’s one classification to tell what type of guys your body is making. IgD & IgE are very rare. In descending order in rarity IgG is the most common, IgA is next and then IgM, the rarest of the three and the one I have. In my last bloodwork, my IgM was listed 326 (definitely not good), which is way up past the high level scale.

Another classification is Kappa & Lambda free light chain and the ratio between them. My Kappa light chain is above normal at 48.49mg/dL. (definitely not good). My Lambda is at 19.10mg/dL, average level. My ratio is 2.56(again not good).

So as you can see, my bad guys are building up an army to do battle with my nonexistent immune system. The symptoms I described in another post are the results of my bad guys progressing into cancer, as it destroys my “B” cells, lymphocytes, platelets as it weakens me and devours my body for food and energy while robbing it from every part of my body. Good luck to you, you could be one of the lucky ones who’s MGUS never progresses into anything but scares the he!! out of you. It could start progressing but stop all of a sudden. Btw, I’m almost 79 and in very fragile condition because I was born with multiple rare health defects. Becky1024

Hi @emurrell65, I know how worrisome it is to potentially have a new health diagnosis. As you can see you’re not alone if the tests do show you have MGUS. I just wanted to make sure you saw this very recent comment from @susanh824 to @hels about her diagnosis with MGUS 10 years ago. It’s very encouraging to anyone diagnosed with MGUS. https://connect.mayoclinic.org/comment/830721/

I’m sure you’re counting the days until April 11. As a veteran/survivor of an aggressive blood cancer, my suggestion is to stay positive and find happy distractions. Read, watch movies, take walks, play with your favorite hobbies, go to lunch with friends, etc… indulge in moments of normalcy instead of focusing on “what ifs”. This will keep your spirits elevated and help you through the anxiety of waiting.
What are some of your favorite pastimes?