MGUS and quite high Free Kappa Light Chain and Kappa Lambda Ratio

I’ve been battling MGUS since May 2019 ever since I realized something was wrong with my bloodwork and asked my PCP to do specialized testing. That’s when my testing and troubles began. The wait and watch testing is standard for MGUS. The 24hr urine test is also an important tool in determining how things may be changing. The urine testing is done to check if you are passing the “M paraprotein”.

It looks for an M Spike, an indication that the paraprotein is progressing (not good) and you cells are headed towards a form of cancer, usually Multiple Myeloma or Lymphoma (mine indicates Lymphoma), my older brother’s was MM and died in 1999,. The number to be concerned about is 0.5 gd/L. Above that indicates your MGUS is progressing towards cancer of some kind. My last bloodwork shows my M/Spike was at 0.56 gd/L (not good). It means my bad guys are on the move and mutating. I pretty much figured that out because of all the new symptoms popping up all around my body.

Now for your Kappa, Lambda question. It’s one classification to tell what type of guys your body is making. IgD & IgE are very rare. In descending order in rarity IgG is the most common, IgA is next and then IgM, the rarest of the three and the one I have. In my last bloodwork, my IgM was listed 326 (definitely not good), which is way up past the high level scale.

Another classification is Kappa & Lambda free light chain and the ratio between them. My Kappa light chain is above normal at 48.49mg/dL. (definitely not good). My Lambda is at 19.10mg/dL, average level. My ratio is 2.56(again not good).

So as you can see, my bad guys are building up an army to do battle with my nonexistent immune system. The symptoms I described in another post are the results of my bad guys progressing into cancer, as it destroys my “B” cells, lymphocytes, platelets as it weakens me and devours my body for food and energy while robbing it from every part of my body. Good luck to you, you could be one of the lucky ones who’s MGUS never progresses into anything but scares the he!! out of you. It could start progressing but stop all of a sudden. Btw, I’m almost 79 and in very fragile condition because I was born with multiple rare health defects. Becky1024

Hi @emurrell65, I know how worrisome it is to potentially have a new health diagnosis. As you can see you’re not alone if the tests do show you have MGUS. I just wanted to make sure you saw this very recent comment from @susanh824 to @hels about her diagnosis with MGUS 10 years ago. It’s very encouraging to anyone diagnosed with MGUS. https://connect.mayoclinic.org/comment/830721/

I’m sure you’re counting the days until April 11. As a veteran/survivor of an aggressive blood cancer, my suggestion is to stay positive and find happy distractions. Read, watch movies, take walks, play with your favorite hobbies, go to lunch with friends, etc… indulge in moments of normalcy instead of focusing on “what ifs”. This will keep your spirits elevated and help you through the anxiety of waiting.
What are some of your favorite pastimes?

I am having my second test done also and an xray for bone imaging and also urine my doctor says i probably dont have it but may have MGUS still i am very worried!!

Hi got diagnosed with mgus last nov still getting my head around everything loads of things i didnt think to ask in consultation my next blood test is in june to check my levels havent changed so i will take a list with me of things i need to ask ...maybe do the same x

Welcome, @emurrell65. I can imagine you're nervous, not to mention confused when your doctor is not yet clear whether the light chains indicate a possible diagnosis of myeloma or monoclonal gammopathy of undetermined significance (MGUS). I've moved your post to this existing discussion:

- MGUS and quite high Free Kappa Light Chain and Kappa Lambda Ratio https://connect.mayoclinic.org/discussion/mgus-and-quite-high-free-kappa-light-chain-and-kappa-lambda-ratio/

I did this so you can easily connect with others who are familiar with MGUS and myeloma. In addition to @frances007, fellow members like @raye @omemee @gina5009 @deborahjb @jart @pmm @myboyzr2 @anng53 @edna68 and many others can share their experiences with testing to get a diagnosis and what to expect.

@emurrell65, you mentioned you will be having more tests. What testing has been scheduled for you as a next step?

I too had a recent lab test which revealed an elevated light chain issue, and the test will be repeated next month. I understand your concern and would make sure you follow up with a hematologist, as I will be doing after I complete the second round of testing. One of my doctors has reassured me that the light chain results were rather low and probably not anything to worry about; however, since my father died of multiple myeloma I too am concerned as you are.

Hi got diagnosed with mgus last nov still getting my head around everything loads of things i didnt think to ask in consultation my next blood test is in june to check my levels havent changed so i will take a list with me of things i need to ask ...maybe do the same x

I am very nervous got diagnosed with light chain disease my doctor said that she does not think it is myleoma, however i am very nervous and anxious. I have to take more test to make sure My doctor thinks it could be Monoclonal Gammopathy unknow, is anyone familiar with this please

I am very nervous got diagnosed with light chain disease my doctor said that she does not think it is myleoma, however i am very nervous and anxious. I have to take more test to make sure My doctor thinks it could be Monoclonal Gammopathy unknow, is anyone familiar with this please

I am very nervous got diagnosed with light chain disease my doctor said that she does not think it is myleoma, however i am very nervous and anxious. I have to take more test to make sure My doctor thinks it could be Monoclonal Gammopathy unknow, is anyone familiar with this please