What are my chances that MGUS turns into multiple myeloma?

Posted by dtrgran59 @dtrgran59, Aug 5 3:26pm

What are my chances that MGUS turns into multiple melanoma
What precautions can I do?

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Profile picture for ladyrose74 @ladyrose74

May I ask what a transient M spike is? I’m also diabetic but I stay very thin, basically eat healthy and exercise and laugh a lot. I didn’t know it could disappear. I think maybe they made a mistake on blood tests. Lymphoma and Lukemia were in my family. I pray for me and everyone.

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@ladyrose74 I found this Mayo Clinic publication where the transient M paraprotein is discussed.
https://www.mayoclinic.org/diseases-conditions/mgus/symptoms-causes/syc-20352362#:~:text=Experts%20don't%20know%20what,By%20Mayo%20Clinic%20Staff
It’s hard to know about lab errors or other anomalies. What does your hematologist/oncologist think?

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Profile picture for mlreptr @mlreptr

Just got a red light therapy mat. Has anyone used a red light therapy mat?

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@mlreptr
I have a red light therapy device that hangs from the wall (or could be put on a stand) which I originally ordered for painful plantar fasciitis that I had on my left foot for almost a year. I was complete amazed after a week how much better my heel felt and after 2 weeks the fasciitis was virtually gone so I am a big believer in this therapy. I used it directed at the bottom of my feet 4-6” away from the device for 10 minutes a day 5 days a week with 2 off. Consistency is the key and now I use it for my back-degenerative disc disease and hopefully for my MGUS but we are in the process of moving from Arkansas to Texas so I haven’t been consistent lately. My IGG and M spike lab markers were improved on my last blood test so I am hopeful this therapy will help in some small way. The device I use is called the Red Rush 400.

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Just got a red light therapy mat. Has anyone used a red light therapy mat?

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Hello. I’m newly diagnosed with MGUS. I would like to know more about the disease and its progression and treatment.
Can someone tell me what 1g G Kappa means?

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Profile picture for ladyrose74 @ladyrose74

My M spike was low and somehow after 18 yrs nothing shows. I have a para protein. I’m sort of confused as I know I am slightly anemic . I had a bone marrow over 18 yrs ago and is what it showed. Now a few months ago my oncologist/ hematologist said on blood tests , no sign of M spike any longer. I have another spot in a few months.

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May I ask what a transient M spike is? I’m also diabetic but I stay very thin, basically eat healthy and exercise and laugh a lot. I didn’t know it could disappear. I think maybe they made a mistake on blood tests. Lymphoma and Lukemia were in my family. I pray for me and everyone.

REPLY
Profile picture for Patty, Volunteer Mentor @pmm

@ladyrose74 now this is something that I was not aware of… Evidently there’s such a thing as a “transient M protein“ which seems to be associated with low levels of the M paraprotein cases.
https://ashpublications.org/blood/article/140/Supplement%201/2338/491379/Transient-M-Proteins-Epidemiology-Causes-and-the
Have you asked your hem/onc physician about this? What does he or she think?

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My M spike was low and somehow after 18 yrs nothing shows. I have a para protein. I’m sort of confused as I know I am slightly anemic . I had a bone marrow over 18 yrs ago and is what it showed. Now a few months ago my oncologist/ hematologist said on blood tests , no sign of M spike any longer. I have another spot in a few months.

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Profile picture for Patty, Volunteer Mentor @pmm

@ladyrose74 and Welcome to the Mayo Clinic Connect! What an exciting development for you! Do let us know what you find out.

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Thank you so much. I send positive energy to everyone

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Profile picture for ladyrose74 @ladyrose74

I have Magus for over 18 yrs. It suddenly disappeared . Cancer ran in my family but so far follow by an oncologist hemotologist is not a cancer and just disappeared.

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I hope you are ok

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Profile picture for dcuste @dcuste

There are different types of MGUS. They don't all progress to MM. For instance, IgM MGUS rarely develops in to MM but more often into WM. I've seen papers claiming the chances are between 0.5% to 1.5% /year. There is also a stage where it is determined to be Smoldering MM or WM. I've seen studies showing that having a low BMI is better than high BMI at slowing progression.

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I have Magus for over 18 yrs. It suddenly disappeared . Cancer ran in my family but so far follow by an oncologist hemotologist is not a cancer and just disappeared.

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Profile picture for 1oldsoul @1oldsoul

@kayabbott
Good morning. I am also 71 and diagnosed with IGM MGUS in 2021. My BMB was normal and my light chains are normal. I have been taking the Qunol Enhanced Absorption Turmeric on and off for several years which really helps my degenerative discs in my lower back. I have read studies that turmeric, milk thistle and even green and black tea can inhibit absorption of iron and my ferritin level did drop from 50 to 25 with no iron storage in the BMB. Did your BMB show the same? My hematologist stated that it’s not uncommon to find no iron storage in women. Has your iron ever been affected by the high dose of Turmeric? Two encouraging signs on my last blood work. My IGG is now in the normal range (IGA still too low) and my M-spike moved down from .4 to .2 now back down to levels 2 years ago. However, because my IGM is in the 700+ range and is continuing to climb about a hundred points a year, my hematologist is concerned that Waldenstrom’s is on the horizon. I recently increased the Qunol dosage from 1500 mg to 2000 mg and will keep increasing it slowly. I have had to start taking iron supplements which seem to be working as my ferritin was 36 on my last test. Thank you in advance for your input.

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I have smoldering MM. I had a year of low ferritin so iron deficient. My hematologist ordered two iron infusions due to the consistent low ferritin. The last ferritin before the infusion was 36. Unknown if it will help, it’s too soon to know, but I can tell you my feet are warm finally!

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