What are my chances that MGUS turns into multiple myeloma?

@pmm
Hi
I have Plasma Cell Lewkemia.
I’m in treatment .5th cycle
Do you think I should tell my siblings ?
Is it possible they our ther children could get it ?
Thank you

@rimord and @redvrm yes, although there are different classifications of MGUS with different risk stratification. Then age and coexisting conditions are also a consideration.
The best person to consult about this is your hematologist/oncologist.
But…
“The three major risk factors for the progression of MGUS are an abnormal serum FLC ratio (i.e., the ratio of free immunoglobulin κ to λ light chains in the serum), non-IgG MGUS, and a high serum M protein level (≥1.5 g/dL) (Figure 1)11,43. Based on the Mayo Clinic’s stratification model, the presence of all three factors constitutes high-risk MGUS. High-intermediate-risk MGUS is present if any two of the factors are present, low-intermediate-risk MGUS is present if any one of the three factors is present, and the absence of all three factors is classified as low-risk MGUS. The risk of progression to LPM at 20 years when one, two, and three risk factors are present is 5%, 21%, and 58%, respectively.”
From the publication below, based on Mayo Clinic’s risk stratification methodology.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9720897/
Will you let me know how this goes for you?

@rimord and @redvrm yes, although there are different classifications of MGUS with different risk stratification. Then age and coexisting conditions are also a consideration.
The best person to consult about this is your hematologist/oncologist.
But…
“The three major risk factors for the progression of MGUS are an abnormal serum FLC ratio (i.e., the ratio of free immunoglobulin κ to λ light chains in the serum), non-IgG MGUS, and a high serum M protein level (≥1.5 g/dL) (Figure 1)11,43. Based on the Mayo Clinic’s stratification model, the presence of all three factors constitutes high-risk MGUS. High-intermediate-risk MGUS is present if any two of the factors are present, low-intermediate-risk MGUS is present if any one of the three factors is present, and the absence of all three factors is classified as low-risk MGUS. The risk of progression to LPM at 20 years when one, two, and three risk factors are present is 5%, 21%, and 58%, respectively.”
From the publication below, based on Mayo Clinic’s risk stratification methodology.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9720897/
Will you let me know how this goes for you?

I believe 1% of MGUS patients progress to full-blown MM. It's a rare malady to begin with. It occurs in only .5% of the population, more so in Blacks, for some reason. If you can get through the first five years of SMM, the chances of it progressing to MM go down. There's a lot of information on the Multiple Myeloma Research Foundation website and, of course, Dr. Google.

i am 95 tears old. was being tested ea year for signsof myelome finsllymydrbwasrestiring a nd he
sta tes that i dinot need to continue blood test, lo and behold my son is 67 and recently fell out of
jis bed and after several emergency he was kept n hosipital. alwa ys hurting inchest. r informed me after
blood test that he had myelom any one /. is this does this seem lik heridtyi

@googi
Thanks for the context. As you have been told and have read, the likelihood of your MGUS advancing to Multiple Myeloma is low.
I would rather not have it, but since I do, it has meant that I get some really excellent healthcare. As others can attest, your hematologist will initually schedule appointments more frequently in order to see how stable your lab results stay. You may also get CT or PET scans to ensure you don’t have bone lesions, indicative of progression to Multiple Myeloma.
Coexisting conditions such as diabetes, age and other indicators of overall general health are considerations, so your hematologist is the best resource for information. Do ask for a consultation if you find that you still have unanswered questions.
Lots of our MGUS members have experienced neuropathy. I started feeling numbness in my feet a couple of years before I was diagnosed with MGUS which in retrospect makes me think I’ve had MGUS a lot longer than my initial diagnosis 4 years ago. There are some medications that may be helpful to you. Ask for a referral to a neurologist if that is not yet happened.
Our members have shared information about diet and supplements that they have found helpful. I am experimenting with 2000mg daily of Curcumin after talking with my PCP doctor, pharmacist, hematologist and other members. My numbers went down but then went up slightly which I attribute to having major surgery. We’ll see if they stabilize when I go back next month.
The link below may be helpful to you about understanding lab results.
I’m really glad you found us.
https://www.myelomacentral.com/livingwithmm/multiple-myeloma-treatment-monitoring/understanding-multiple-myeloma-lab-test-results

Thanks so much for your information-packed message and for the link regarding understanding lab results. The hematologist also mentioned Curcumin as perhaps being beneficial. How did you determine the correct dosage? BTW, it’s a gorgeous plant!

@mlreptr
I have a red light therapy device that hangs from the wall (or could be put on a stand) which I originally ordered for painful plantar fasciitis that I had on my left foot for almost a year. I was complete amazed after a week how much better my heel felt and after 2 weeks the fasciitis was virtually gone so I am a big believer in this therapy. I used it directed at the bottom of my feet 4-6” away from the device for 10 minutes a day 5 days a week with 2 off. Consistency is the key and now I use it for my back-degenerative disc disease and hopefully for my MGUS but we are in the process of moving from Arkansas to Texas so I haven’t been consistent lately. My IGG and M spike lab markers were improved on my last blood test so I am hopeful this therapy will help in some small way. The device I use is called the Red Rush 400.