Metastatic Castration Resistant Prostate Cancer (mCRPC)

I know a guy who went to Austria and had actinium treatment. There’s a real problem with saliva drying up almost completely after actinium so be prepared to need liquids while you’re eating in order to be able to swallow. They’ve apparently been working on trying to fix that problem, but it’s just one of the side effects.

The guy I know that went over there was not producing much PSMA, As a result, the actinium was not Successful. While he was there, and they actually ran him through Pluvicto as well, And even though he didn’t have BRCA they even tried a PARP inhibitor. He didn’t survive a year.

Actinium looks like it has a lot of promise, but the side effects are quite problematic.

Hi Jeff always great to read your inputs. It sounds like the two drugs killed him? Am I reading that correctly?

No, the cancer killed him. Unfortunately, the two treatments didn’t help at all.

It may have been he had some neuroendocrine cancer and that’s what really shortens his life and is not treatable by those two treatments.

Thanks for the reply. Have you read anything regarding administering Doxorubicin + viagra for treatment of prostate cancer. Some studies suggest it’s quite effective.

I have neither read nor heard from anybody about that.

I do attend seven advanced prostate cancer online meetings every month, Not a subject that has been broached.

Reading about it, it seems that doxorubicin can damage the heart. I know that for myself, I would not even want to take a chance because of the damage Zytiga has already done to my heart.

A combination of Viagra (sildenafil) and doxorubicin has been shown in pre-clinical studies to enhance the killing of prostate cancer cells by increasing reactive oxygen species and activating cell death pathways, while also protecting the heart from doxorubicin-induced damage.

Sildenafil can also protect the heart from the damaging side effects of doxorubicin, a well-known cardiotoxic drug, by reducing left ventricular dysfunction and cardiomyocyte apoptosis

It’s interesting because doxorubicin seems like a very effective kill agent. As potentially lethal as it is it might be better than pluvicto.

How long did he have prostate cancer?

That I didn’t find out. He came to three different ancan.org Online Advanced prostate cancer meetings About a year ago.

He talked a lot about his treatments in Austria before and after going over there.

I know that he had it for at least a few years, but there are so many meetings and so many people that it’s really hard to keep track of every detail. The treatments he got just stuck out because they were so different from everybody else.

I found this information:
Here’s what I found regarding the combination of doxorubicin (a chemotherapy agent) and Viagra (sildenafil) in the treatment of prostate cancer:
Scientific Basis & Preclinical Findings
1. Enhanced Cancer Cell Killing & Cardiac Protection
Lab studies and mouse models have shown that sildenafil (a PDE-5 inhibitor) enhances the effectiveness of doxorubicin against prostate cancer cells. This combo:
Boosts apoptosis (cell death) in PC-3 and DU145 cancer cells.
In mouse models, the combination significantly reduced tumor size while also protecting against the heart damage doxorubicin typically causes.
2. Mechanistic Insight—DNA Repair Disruption
Further research showed that sildenafil impairs the cellular DNA repair systems (both homologous recombination and non-homologous end joining). This makes doxorubicin-induced DNA damage more lethal to cancer cells.
3. CD95-Mediated Apoptosis
Another pathway involves modulation of CD95 (Fas receptor) and its inhibitor FLIP. Sildenafil plus doxorubicin reduces FLIP levels, enabling CD95 to drive more potent apoptosis in prostate cancer cells.
Clinical Evidence & Early Human Data
There is very limited human clinical trial data for this combination, but one randomized study did explore it:
Safety vs. Efficacy: In a clinical study examining doxorubicin with and without sildenafil, the combination was generally tolerated with mostly mild side effects (e.g., headache, flushing). However, a concerning decline in left ventricular ejection fraction (LVEF) occurred in one patient—but that individual was also on trastuzumab, making it unclear whether sildenafil was responsible. Ultimately, the trial continued, but found no evidence of cardiac protection from adding sildenafil.
Summary:
“There’s promising preclinical evidence showing that sildenafil can enhance doxorubicin’s cancer-killing effects—by impairing DNA repair pathways and promoting apoptosis—and even toggle some heart protection in animal models. However, in the limited human data available, sildenafil didn’t reduce heart damage and didn’t show treatment benefit. More clinical trials are needed before this combination can be considered for actual use.

That seems like an extremely effective kill agent but the cardiac risk seems extremely high. Thank you so much for that educational reply greatly appreciated.