MDS now progressing to AML and need to decide if time to start Vidaza

Posted by grat1963 @grat1963, 14 hours ago

My 67 yr old sister has been in the hospital since June 3rd and I have to make a decision for her. She was diagnosed with MDS July of 2024 with del 5q as well as the TP53 gene mutation. She went into the hospital in June for a UTI and pneumonia and eventually fell into a neurologic delirium and had to be intubated and ended up in the ICU. They discovered that her MDS is progressing towards AML - 12% blasts in the bone marrow now. Although she is now extubated and is beginning to wake up, she spends most of her days still mostly sleeping and has yet to talk. She also is still not swallowing so she's on a feeding tube. And furthermore, she had to go on dialysis in the middle of all of this! I am beyond sad for my sister and all of our family. The oncology team at the hospital wants me to decide about putting her on Vidaza. Has anyone here had any experience with Vidaza plus the TP53 gene mutation OR taking Vidaza while being on dialysis?

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