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Lupron & Lynparza Treatment, What's Your Experience?
PC diagnosed late 2024, Stage 4, Gleason 9,in multiple bones and lymph nodes. PSa 73. Placed on lupron and Nubeqa. Chemo early 2025 knocked psa to 0.058. Recently psa moving upward. May 2026, Placed on Lynparza. Off Nubeqa. Still on Lupron. RBC down and fatigue up. Anyone have experience with my current treatment?
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Do you have BRCA1 or BRCA2? Do you have some other genetic problem? Lynparza Only works to help people that have genetic problems and it really works with BRCA much better than other Genetic problems.
Lynparza Makes a lot of people anemic. It reduces the red blood cell white blood cell and platelet counts quite a bit. If you don’t have one of the genetic problems, I would ask my doctors what’s going on, why am I getting this?
Have you had chemotherapy or Pluvicto Yet?
I know people who have been on lynparza, it has worked, but the length of time it has worked is varied.
I have BRCA2 so when what I take now stops working, I will go on lynparza. My oncologist has wanted me to hold off until all the drugs stopped working because it’s so hard on the body. Orgovyx and Nubeqa Do still work for me, fortunately.
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1 Reaction@jeffmarc not sure on the genetics. Seeing the Doc 8/10/26. Will discuss. Thanks Bro.
@jeffmarc I have the CDK12Y849 mutation. Seems to be rare. Doc says Pluvicto will appropriate if PSA gets up to 4. Currently it is 0.582. Staying with Lynparza for now.
@davehohman
Has lynparza made a noticeable difference? Has it kept your PSA from rising or at least kept it rising slowly? Are you on ADT as well? Any other cancer drugs?
I have heard it as one of the genetic problems that can be helped by a PARP inhibitor.
@jeffmarc yes psa rising slowly. On lupron. Moffit is nearby in Tampa if needed.