Lupron & Lynparza Treatment, What's Your Experience?

Do you have BRCA1 or BRCA2? Do you have some other genetic problem? Lynparza Only works to help people that have genetic problems and it really works with BRCA much better than other Genetic problems.

Lynparza Makes a lot of people anemic. It reduces the red blood cell white blood cell and platelet counts quite a bit. If you don’t have one of the genetic problems, I would ask my doctors what’s going on, why am I getting this?

Have you had chemotherapy or Pluvicto Yet?

I know people who have been on lynparza, it has worked, but the length of time it has worked is varied.

I have BRCA2 so when what I take now stops working, I will go on lynparza. My oncologist has wanted me to hold off until all the drugs stopped working because it’s so hard on the body. Orgovyx and Nubeqa Do still work for me, fortunately.

@jeffmarc not sure on the genetics. Seeing the Doc 8/10/26. Will discuss. Thanks Bro.

@jeffmarc I have the CDK12Y849 mutation. Seems to be rare. Doc says Pluvicto will appropriate if PSA gets up to 4. Currently it is 0.582. Staying with Lynparza for now.

@davehohman
Has lynparza made a noticeable difference? Has it kept your PSA from rising or at least kept it rising slowly? Are you on ADT as well? Any other cancer drugs?

I have heard it as one of the genetic problems that can be helped by a PARP inhibitor.

@jeffmarc yes psa rising slowly. On lupron. Moffit is nearby in Tampa if needed.

12 years on Lupron every 7-9 months. Shortly after Covid about 2 years ago my PSA went from 0.06 to 2.78. Just recently while still on Lupron every 3 months my PSA went to 4.6. My oncologist suggested oliparp, (after I had genetic testing), if my PSA continues rising and a scan shows metastasis. My question is the side effects with oliparb. How are you doing on it. How long on it. Any information available from patients on oliparp would be useful and appreciated. Thank you Irwin

Lupron shots must be given no less than every six months. If you’re going longer than that, then the shot has worn off, but of course your testosterone doesn’t come back real quick. You don’t mention your Gleason Score or whether or not you have any of these aggressive problems.

Were any of these things found in the biopsy intraductal, ductal, large cribriform, Seminal vesicle invasion, EPE or ECE. (Extraprostatic extensions extra capsular extensions). They can make the cancer much more aggressive.

The fact that you are having a rise and PSA while on ADT means that you are castrate resistant. It happened to me 2 1/2 years after Starting ADT and I was immediately put on an ARPI. The fact that your doctor has not done this means that you need to find a new doctor. The advice you were getting is not standard of care and I have run into many people that have been badly treated by their doctors and ended up with very advanced cases as a result. Most of them wanna see their doctors for how they were treated. There are a few people in this forum with that problem.

If you mention where you live, maybe we can give you the name of the doctor in your area, but you are not being treated right now using the standards doctors should follow..

Olaparib is a drug that is mainly useful if you have The genetic problem of BRCA. I have BRCA2 so for me it is a drug I can use, but after 16 years of prostate cancer, I have not used it yet. Other drugs have worked better for me..

The problem is that olaparib Has some very strong side effects. Half of the people on it become anemic. It reduces the red blood cell, White blood cell, Hemoglobin and platelet counts by a lot.

Considering your situation you should actually be on an ARPI. That is called the standard of care. I was put on abiraterone (Zytiga) When my PSA hit .2 while on Lupron. The fact that your doctor has let your PSA rise so much without putting you on one is just not good practice and not good for you. It is now six years after I became castrate resistant and I’ve been undetectable for the last 34 months while I’ve been on Orgovyx and Nubeqa. When those drugs fail, I will then start olaparib But it is not the right drug for me now. You need to have hereditary, genetic testing before you even consider using that drug. You should also have somatic, genetic testing. It is possible that you can have a genetic problem that is not hereditary, but it’s just created by your cancer.

Please find yourself another doctor get a second opinion from somebody else. You’re overall survival is dependent on you doing something more than being done now.

@ihboat, welcome. I moved your question about Lynparza (olaparib) to this related discussion:
- Lupron & Lynparza (olaparib) Treatment, What's Your Experience? https://connect.mayoclinic.org/discussion/lupron-lynparza-treatment-whats-your-experience/

Click the link to read previous posts and connect with members like @davehohman @iboy @soflada who have experience with olaparib.

@ihboat, has the scan confirmed or ruled out metastasis? How are you doing?

Metastasis was determined 12/24. Multiple locations in bones and lymph nodes. Gleason 9. Chemo knocked the locations down to 2 spots on left hip as shown on the 7/26 PET SCAN. Blood Tests 9/21. Biggest problem has been fatigue since starting Lynparza in May 26. RBC has gone down like it did with chemo.

@davehohman
A PARP inhibitor not only reduces your red blood cell count. Also your platelets and your hemoglobin.. Many people on PARPs have anemia and need blood transfusions.

I have BRCA2 and have held off for 16 years now because the extreme side effects from the PARP. My oncologist has also discouraged my using it until the ADT and ARPI drugs both fail.

Do you have BRCA2? PARP Inhibitors have not proved to be real effective if you don’t.