1. < Osteoporosis & Bone Health

Can long-term use of SSRIs possibly contribute to osteoporosis?

Posted by dancingtree @dancingtree, Dec 3, 2020

I have been on 225mg venlafaxine (Effexor) for 25 years and I am now 68yo. I was diagnosed with osteoporosis about 13 years ago. I took a bisphosphonate for 5 years. Have been off for a few years now and my numbers went up again. Doc now wants to put me on Prolia. In my research I just read that taking SSRI antidepressants can contribute to osteoporosis. So I am thinking that this drug has given me a bone condition and now I need to take another drug to counteract it? I have tried to get off of venlafaxine a dozen times with very bad side effects. I kept asking my doctors what are the long term effects of taking this SSRI for so long and they didn’t seem to know anything. Also, they said that the severe side effects of going off meant that I needed to continue taking the drug! Anyone have an insight into this situation?

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mannism | @mannism | Dec 4, 2023
In reply to @llynch17056 "I’m not sure the image uploaded so I’ll describe it. Nature Nade, high absorption Magnesium Glycinate,..." + (show)
@llynch17056

I’m not sure the image uploaded so I’ll describe it. Nature Nade, high absorption Magnesium Glycinate, 200 mg, 100% chelated. I take two capsules at night an hour before sleep time. I chose this on on recommendation from a friend and a lot of reading.

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Recommended daily magnesium dose is 300 mg. I took what you take for years and started having irregular kidney function readings on blood tests.

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HomeAgainLA | @llynch17056 | Dec 4, 2023
In reply to @mannism "Recommended daily magnesium dose is 300 mg. I took what you take for years and started..." + (show)
@mannism

Recommended daily magnesium dose is 300 mg. I took what you take for years and started having irregular kidney function readings on blood tests.

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Wow! THANK YOU! I will reduce that to one cap daily of 200 mg.

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Christine | @thisoldewe | Dec 5, 2023

So sorry to read of your situation. Have you talked to your Pharmacist? They may be able to give you more insights and are a wealth of information.
The only comment I can make re SSRIs, is that discontinuing must be extremely slow over many months. I'm sure you are already aware of that.
All the best in your researching.

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