It is called something that begins with an O..Onivide I think it is spelled
He has his chemo treatment every other week
He is in the clinic while this chemo is infusing for about an hour
Then he gets something to enhance the chemo called Leukovorin for 30 minutes
Then is is attached to a pump with 5 FU infusing for 46 hours
We go home and come back 2 days later when that has finished infusing and it is disconnected
Then he is free for 12 days
Dana Farber in Boston
The chemo regimen he is receiving is Nalirifox if it contains Onivyde. This drug is micro particles of irinotecan with a liposomal,coating. It gives the drug the ability to be more deeply internalized into the cell and then the high concentration of irinotecan is released. It remains in the body longer for enhanced cytotoxic effects. It was recently approved by the FDA in February 2024.
The title of the abstract is “Comparitive effectiveness of MALIRIFOX vs. FOLFIRINOX in pancreatic cancer. Authors are Xiayu Jiao of Department of Pharmaceutical and Health Economics, USC Schaefer Center, Los Angeles, CA and Afsaneh Barzi from City of Hope Comprehensive Cancer Center, Duarte, CA.
Conclusions of the study:
Compared to Folfirinox, there is slightly higher Quality Adjusted Life Years.
Marginal Progression-Free Survival
While the cost of treatment using Nalirifox is significantly more (56%) than using (m)Folfirinox, some of that is offset when comparing adverse event rate of Neutropenia, Febrile Neutropenia, Anemia, Diarrhea and Thrombocytopenia and its monthly management costs being lower with Nalirifox of 3:1.
It is called something that begins with an O..Onivide I think it is spelled
He has his chemo treatment every other week
He is in the clinic while this chemo is infusing for about an hour
Then he gets something to enhance the chemo called Leukovorin for 30 minutes
Then is is attached to a pump with 5 FU infusing for 46 hours
We go home and come back 2 days later when that has finished infusing and it is disconnected
Then he is free for 12 days
Dana Farber in Boston
X Corporeal Shockwave Therapy-
Has anyone heard about this? Some very interesting results with cancer patients and in particular a pancreatic patient in Germany. Used for years to heal wounds but now being used to target tumors .
Thank you for that article as it exemplifies how a stage 4 patient can now have surgery! I’m wondering if it only works on tumors versus lesions in the liver?
It is so easy to think any lesion on the liver is cancer. Of course the radiologists reading have diagnostic criteria, but usually a biopsy seems to be the ultimate but perhaps the most uncomfortable and high risk final diagnosis. My husband had some seen on CAT scans that disappeared in subsequent ones during active immunotherapy and may have been, but no one really attributed it to them there are a number of types of sources of liver lesions from what I understand that have their own sets of characteristics. However while in active therapy, their disappearance could mean that immunotherapy worked on them. Just recently, My husband had sepsis from an obstruction due to G.I. adhesions from the initial pancreatectomy. Following that a CT showed a liver lesion. A follow up liver MRI continued to show it. All of the doctors and tumor board couldn't decide if it was infection or cancer without a biopsy. My husband weighed in on what he didn't want to do and he wasn't crazy about a biopsy. The decision was to wait and see from that liver MRI for one month. At the end of the month there was clear radiologist/MD recognition that the lesion was from infection and that it was nearly totally dissipated at the second MRI. So sometimes infection can be good news instead of more cancer. My husband had been free from visible CT cancer lesions for 2 years when this happened. This next week is our 5th year anniversary of fighting pancreatic cancer.
Do you happen to have his email still? I tried calling there this morning but they would not let me through to him or give me an email. We are far away as well and I was hoping to have a little prelim info about if my father would be a possible candidate or not for that before we commit to traveling so far.
I had lesions on my liver when first diagnosed, and was told chemo was the only option. I may have had nodules starting in my lungs too, CT was ambiguous, but if so chemo has cleared them up as well as slightly shrinking lesions on my liver.
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The chemo regimen he is receiving is Nalirifox if it contains Onivyde. This drug is micro particles of irinotecan with a liposomal,coating. It gives the drug the ability to be more deeply internalized into the cell and then the high concentration of irinotecan is released. It remains in the body longer for enhanced cytotoxic effects. It was recently approved by the FDA in February 2024.
The title of the abstract is “Comparitive effectiveness of MALIRIFOX vs. FOLFIRINOX in pancreatic cancer. Authors are Xiayu Jiao of Department of Pharmaceutical and Health Economics, USC Schaefer Center, Los Angeles, CA and Afsaneh Barzi from City of Hope Comprehensive Cancer Center, Duarte, CA.
https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.4160Conclusions of the study:
Compared to Folfirinox, there is slightly higher Quality Adjusted Life Years.
Marginal Progression-Free Survival
While the cost of treatment using Nalirifox is significantly more (56%) than using (m)Folfirinox, some of that is offset when comparing adverse event rate of Neutropenia, Febrile Neutropenia, Anemia, Diarrhea and Thrombocytopenia and its monthly management costs being lower with Nalirifox of 3:1.
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2 ReactionsIt is called something that begins with an O..Onivide I think it is spelled
He has his chemo treatment every other week
He is in the clinic while this chemo is infusing for about an hour
Then he gets something to enhance the chemo called Leukovorin for 30 minutes
Then is is attached to a pump with 5 FU infusing for 46 hours
We go home and come back 2 days later when that has finished infusing and it is disconnected
Then he is free for 12 days
Dana Farber in Boston
@bceg1969 - May I ask, what type of chemo is your husband receiving for both pancreas and liver cancer?
X Corporeal Shockwave Therapy-
Has anyone heard about this? Some very interesting results with cancer patients and in particular a pancreatic patient in Germany. Used for years to heal wounds but now being used to target tumors .
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Hug
2 ReactionsThank you for that article as it exemplifies how a stage 4 patient can now have surgery! I’m wondering if it only works on tumors versus lesions in the liver?
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1 ReactionDr. Christopher Wolfgang, chief of the Division of Hepatobiliary and Pancreatic Surgery at NYU Langone Perlmutter Cancer Center suggested his stage IV adenocarcinoma patient undergo histotripsy (ultrasound ablation) for 4 liver mets before Whipple. Article from March 28, 2024. https://nyulangone.org/news/nyu-langone-cancer-specialists-use-pioneering-histotripsy-technology-noninvasively-treat-liver-tumors
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5 Reactions5 yr survival..love to see that
My husband did have the bx and they are cancer . The chemo he is on now is supposed to treat his pancreas and liver🙏🏽
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1 ReactionIt is so easy to think any lesion on the liver is cancer. Of course the radiologists reading have diagnostic criteria, but usually a biopsy seems to be the ultimate but perhaps the most uncomfortable and high risk final diagnosis. My husband had some seen on CAT scans that disappeared in subsequent ones during active immunotherapy and may have been, but no one really attributed it to them there are a number of types of sources of liver lesions from what I understand that have their own sets of characteristics. However while in active therapy, their disappearance could mean that immunotherapy worked on them. Just recently, My husband had sepsis from an obstruction due to G.I. adhesions from the initial pancreatectomy. Following that a CT showed a liver lesion. A follow up liver MRI continued to show it. All of the doctors and tumor board couldn't decide if it was infection or cancer without a biopsy. My husband weighed in on what he didn't want to do and he wasn't crazy about a biopsy. The decision was to wait and see from that liver MRI for one month. At the end of the month there was clear radiologist/MD recognition that the lesion was from infection and that it was nearly totally dissipated at the second MRI. So sometimes infection can be good news instead of more cancer. My husband had been free from visible CT cancer lesions for 2 years when this happened. This next week is our 5th year anniversary of fighting pancreatic cancer.
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Helpful -
Hug
6 ReactionsSorry. I didn’t see this post. And I don’t have the email.
I would call and make an appt. They can consult with you virtually for ur appt.
Thank you for that positive information