LINZESS 145CMB

I hope you get some responses. I took it 3 days and had no reaction. I read on this site that it takes 2 weeks to kick in and I don’t have 2 weeks to wait near a bathroom. So, I doubt I’ll try it again.

I was first on Amitiza, zippo.
Next Linzess, helped some.. I was on 145mcg 2x day.
Now, Trulance, same as Linzess, different name and cheaper for my insurance.
17 years of CIC, same GI specialist...who neglected to mention that my CIC was so bad that I would need to keep using megadoses of miralax also.
I am assuming you must have bad CIC...if that is the case, read up on Hyperparathyroidism and elevated calcium. I went to 3 drs before I started to believe that I really did have this problem and that it wreaks havoc on smooth muscles in the whole body, my colon no longer contracts-release to push 💩 out. So, I have to keep my bowels in constant fluid/diarrhea, or it is not going to come out. I use 3-6 capfuls of miralax a day and throw in some Metamucil powder or gummy's a couple of times a week. I never leave the house cuz I don't know what might happen or not happen. Good luck. I have surgery in 3 weeks to remove probably 3 1/2 of the 4 parathyroid glands.

That sounds very intense. Good luck with your surgery. I appreciate the tips.

I have had normal calcium levels twice since this started. And, I’ve discussed it with my Endocrinologist twice, who doesn’t think it’s any hormonal imbalance. What test would they use?

I do okay with 1 cap of daily Miralax. I just don’t think that should be required since I’m so healthy, except for post covid syndrome which occurred after my chronic constipation.

I'm glad you are in touch with an endocrinologist. Hyperparathyroidism can't be diagnosed with a one time test. It needs to have several sets of blood tests, calcium, vitamin D, and PTH, possibly other metabolic blood tests. Calcium is supposed to be tightly regulated by the PTH glands. Because low or high is bad. As I mentioned I have had 3 different dr. Opinions and did tons of my own research...cuz I knew nothing about HPTH, until it got tested 18 years ago, when my PCP couldn't find why my vit D was so low and my PTH was so erratic (32-188).
You are right, since you are healthy, you should not have to take any medication. Good luck with your hunt.

I had a high calcium blood test and my Internist sent me to a Thyroid/Parathyroid surgeon (that is all he does). He performed an ultrasound in the office and results showed one gland the size of a grape and the others were normal, size of a grain of rice. He removed the grape sized gland, and I had immediate results the next day from one of the symptoms and over a few months the others subsided. Good luck and know that all the crazy symptoms that make you wonder if you ARE crazy, because they come and go and don't all occur at the same time, will go away.

OH MY GOODNESS!!!!
You have no idea how desperately I needed to hear this today. I am scheduled for surgery in 2 weeks and I got yet another conflicting comment from a doctor. I have even had long exchanges with AI-POE, it's amazing how much solid evidence based info AI-POE is like another opinion.
Would you be willing to share what caused your dr to test your calcium, how high was your calcium, how long was it high, what was your vitamin D and PTH levels? Would you elaborate on the immediate symptom improvement, later improvements.
😇😇😇 you are the angel with info, that I needed. Thanx so very much Shelley