How long do Lupron side effects last after treatment concludes?

"Jbuuck" and all,
At 77 years old I had my last Lupron shot 1/4/24.
My sides were: hot flashes - still but maybe a bit less frequent. Hair loss on my body - but arm hairs are re-growing, muscle mass & strength way down - with no improvement yet, fragile skin - no improvement but that could be just age, the RARP took my sex drive, mood and concentration remained good and I'm better than ever now.

Like you, I'm mostly anxious to get rid of the hot flashes and regain muscle.
Best of luck to you and all of us with these annoyances.
But I'm doing all I can to enjoy life: 2 grown sons, 4 wonderful grand kids, and a Lady Friend who likes concerts, social gatherings, and fast cars 🙂
All the best to you and all our Brothers!
- GranPun

I ve been on Zytiga for every three months. It makes me not as tired as you talk about- been 18 months now. I get things done in the am and nap in the afternoon after lunch. I m 75. Not worried about ED at my age. I exercise daily and eat the right foods too, give Tumeric a try. Good for people with cancer. Hope this helps ya

I think that a lot depends on your condition when you begin I was on lupron and Erleada for a year. Had some hot flashes, loss of muscle, no sex drive, slept poorly but over all it was manageable I have been told that if the cancer returns so will these meds. Very happy to be alive at 77

I am thisisit66, I have had prostate cancer since 2006 and it was getting to the point that I had to do something. I also have Stage V kidney failure and have been on PD dialysis for 4 years. I have been wanting to get a kidney transplant but I had to get the prostate treated. I am 76 years old and until I started the Lupron, considered myself to be in good shape. I had radiation treatment for the prostate then started a regimen of Lupron. First two or three month treatments, then a 6 month treatment - since I had been doing so well. The 6 month treatment KICKED my butt. Took my muscle strength, any stamina that I may have had, and made be exhausted all the time. My PSA had dropped like a rock but the cost has been huge. After a year of treatment, I am thinking about stopping them but I have not consulted my urologist. I feel like a shriveled old man now and I hope I can recover. The ED really has me down and I don't think that is going to recover.

I am wondering how other men have recovered after treatment. This thread has given me some good info but I would like to read how many other men have done.

Thank you, thisisit

Yes, sadly it is not curable. I now look at as a chronic disease such as diabetes. We have to learn to live with it, treating regularly, and adjusting to its changes as well as our bodies changes. Many parts of this journey are difficult and even painful. For me the emotional struggle has been much worse than the physical struggle, but I have not yet experienced any significant pain from the cancer. I am having increasing joint issues, but they are likely a result of my active and irresponsible youth, along with now being 70, as much or more than the cancer. I am reasonably sure that the drugs (lupron and Cassodex) stripping much of my muscle mass have also contributed to the joint pain. Pilates has helped a lot. I work hard on compartmentalizing the cancer and a good friend gave me the best advice: “its ok to have a bad day and give yourself a pity party, but don’t allow yourself to have two bad days in a row”. So periodically I feel down and I accept it, share with my family that it’s a bad day, and lay low. But the next day I get up out of bed and live. I have found that dealing with it this way has also really stretched out the periods between feeling bad.

Update:
I decided to get a baseline testosterone reading going forward now that I have decided not to take the 3 (out of 4) additional Lupron Depot therapy injections. The results just out < 20 Total T so have my work cut out for me. Normal is
I have/am experiencing all of the following side effects I’m optimistic that with diet and exercise over time T will return to normal range. Normal is approx +150-800 for a male my age.

In males, lower testosterone levels can lead to:

hair loss
a reduction in muscle tone
more fragile skin
a reduced sex drive
mood disturbances
memory or concentration problems

Started with Lupron Depot injection followed by 20 radiation sessions in 2023. Was administered the maximum 6 month 45mg dosage. Had Gleason score of 8 intermediate high risk. PSA 15. Cancer confined in Prostate with possible microscopic in lymph nodes. Radiation attacked both areas. After treatment early December PSA reading was full remission. However, since taking the LD injection I have been diagnosed with Bradycardia (slow pulse rate) and irregular heart beat so decided to stop the LD injections (4 total over 2 years was plan) in the hope that my heart will return to normal. My radiologist is in agreement that I stop. Most side effects were from injection include hot flashes, libido loss, testicular shrinkage, man boobs and others possibly caused by the injection. Side effect from radiation is incontinence while standing urinating at times. I am hopeful all will go away over the next 6-18 months. I am 80 and feel fine, My best to all posting here.

Layman opinion: Stay with the devil you know.
I took Orgovyx for 4 mos as part of my salvage radiation w/ ADT tx.
If your side effects (SEs) are manageable for you, I would be inclined to stay the course.
It sounds as if you restarted Lupron in Nov 23.
If you are on holiday again, you could try Orgovyx.
However it may cost you significantly more because it is covered under Part D Medicare as opposed to the coverage for injectables under Part B Medicare.
My Part D coinsurance
cost was 25% or about $ 1000 / mo for Orgovyx until I reached the catastrophic stage ( after 4/5 mos, but I cannot explain the math).
Best wishes for good results.

mauinokaoi,
I'm replying with the orgovxy site because it shows you a timeline with testosterone supression between the two lupron and orgovyx. Orgovyx provides a more steady dose because you take it everyday. We don't know what the psa does between lab draws, I assume it rises and falls with the testosterone levels.
I know far less than you do about all this. https://www.orgovyxhcp.com/efficacy/

I don't know anything about it. Check with your Doctor or Her / His NP for risks and benefits of each; and if you have additional health issues is that / are they factors in selecting this medicine over another. God Bless.