LDLs high due to Prolia?

Posted by jheieck @jheieck, 13 hours ago

I've posted here before re: my issues with taking Prolia and experiencing severe problems with my jaw during dental treatment. I have managed somehow to get through 3 years of hell with implant placement, timing the work around Prolia injections. Both implants failed twice due to infection and bone loss, but both have finally succeeded. But, after 9 years I am ready to go off Prolia. My recent bone density scan shows that I am now downgraded to osteopenia, and a couple of my scores are actually in the normal range. I attribute this change to having one of my parathyroid glands removed about a year ago, due to a tumor. I no longer have hyperparathyroidism. My PTH levels are in the normal range and so are my calcium scores. Now I face another dilemma. I recently had a scan of my heart calcium and at 72 my arteries are about 50%. My HDLs are high but so are my LDLs. I'm now a candidate for taking statins, but I'm terrified of those side effects, and I do not want to be on this drug the rest of my life. I'll add that I also lost 48 lb in the last year and a half by taking a GLP-1 and I understand that it's possible statins can interfere with GLP-1 efficacy. I also strongly believe my mother's dementia was a side effect of taking statins for so many years. I'm desperately wanting to get off Prolia, especially now given the fact that my LDLs are higher than they should be, given my lifestyle and dietary choices. My physician mentioned I could go on one year of Reclast and then transition to a lower strength drug after that, but after reading so many things about Reclast side effects ( I already have severe bone pain that I've dealt with being on Prolia all these years), I don't want more side effects. Does anybody have experience with having high LDLs attributed to Prolia use? Also does anybody have any suggestions about whether someone like me who now is in osteopenia can go off of Prolia altogether? Is that even an option for me? I'll say one last thing and that is I've never had one fracture, not one. And I've fallen several times over the years. I don't know why my doctor put me on Prolia in the first place? Maybe because it was a new drug? I wish I knew then what I know now about this drug. I'm so sad that I've had to live like this for so many years. I won't even go into the expense and the difficulty getting it through insurance. That is a whole other topic.

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