Last PSA Number Before Cancer Diagnosis?

17.5.
Watched it go from 5.75 in 2016 and rise slowly over the next 6 or so years. Monitored regularly but COVID put a dent in those arrangements I chose proton beam therapy in 2023. Doc said ADT wasn’t necessary. I didn’t argue.

Cole Sir , this seems really odd . Never heard of 90+ cores for a biopsy . Was there a reason given ? James on Vancouver Island !

Mike , I was 4.1 at surgery time 5.5 years ago . Good luck Sir!

There are so many frustrating exceptions, "what if's", and oddities that fail to properly categorize the type, the treatment, or the longevity/outcome of prostate cancer, that it is almost pointless to try to figure out what is going on within each of us. For a cancer that has Gleason Scores, and "Type", and sub-types depending on what microscopic features there are or aren't, it is a wonder why we bother trying to figure it all out, knowing that "our" own particular case won't fit the mould, leaving us to wonder why...why me?
I remember asking during my biopsy and again when hearing/receiving the biopsy results: "So, a Gleason 3+3 = 6 or a 3+4 = 7 can't be an aggressive form of cancer...that is more like an 8 or 9?" to which my urologist said "exactly" in his agreement. That changed "post-op" for me when we got the surgical pathology report: my urologist said, "Hmmm...it seems 'you have' an aggressive form of cancer despite being a Type 2 and a Gleason 3+4=7. You have EPE, surgical margins, left seminal vesicle invasion, and cribriform glands...we need to talk about radiation at your next visit." I prepared myself for that discussion but then...He backed off that plan when we got a < 0.1 ng/ml ("zero") PSA at three months. Now it is "let's wait and see what your next PSA is in 3-months", despite now being a pT3b that has a known behavior to see the cancer return within 1-5 years no matter what is done with radiation or meds. This is driving me crazy. I had a 40-year clinical career in laboratory medicine. LEUKEMIA is more straight forward than prostate cancer. There are eight (8) types of Leukemia. They each behave and respond pretty much the same way, with little or no variation. Prostate cancer is nearly always an adenocarcinoma, yet you've got these crazy "ya but" situations that change everything: bladder neck involvement, EPE, surgical margins, cribriform glands, seminal vesicle invasion, perineurial invasion, potential lymph node involvement, Decipher Test genes and score, etc. all of which change your category, treatment, and outcomes to include probability of recurrence within a specified time, despite the fact that the urologist removed the damn prostate, vas deferens, and seminal vesicles. This disease is exasperating.

Yes, after speaking with my Doctor and confirming it was 24 not 94 cores. Plus I have already completed 14 core biopsy which was negative. I asked the doctor do we keep doing biopsies if this one came back negative also he was not sure how to reply?

Mine was 5.53. Back in 2006.

MRI and PET scan were both inconclusive. Both were done at the VA in Gainesville, Florida. Although I have Tricare for Life as a military retiree, so far, the treatment and organization of my visits have been satisfactory. I could easily go to Mayo in Jacksonville, but so far will remain with VA. 2010 diagnosis was prostate cancer after two biopsies; Gleason 3 plus 3; PSA 6.47.
Proton radiation at Loma Linda for 2.5 months (modest radiation over a longer period of time minimizes post-radiation issues). Never ever had any problems. The last five years, PSA has been rising, hence my comments. Could be BPH or other. Sometimes the issue is modest infection. The treatment is usually with antibiotics like Cipro. Avoid surgery at all cost..the implications and life style changes could be significant. 05/11A Florida

Here's all the history that shows up on MyChart. When it hit that 4.6 after staying down while on Finasteride and Flowmax for over 3 years they ordered another MRI, PiRad 5 they said, then another biopsy showed a Gleason scores of 7's and one 8. Had a removal May 5th. PSA last week was < 0.1.
PSA Test history:
2016: 1.8
2018: 3.0
2019: 3.6
2021: 5.5, 5.5 and 5.8
2022: 2.4, 4.3
2023: 3.6, 3.9 and 3.7
2024: 3.7 and 4.6
2025: < 0.1 first post op PSA.

My PSA was under 1.0. My internist did a digital rectal exam during my annual physical--not always done and very lucky for me. He felt a nodule and referred me to a Urologist. The Urologist was reluctant to do anything because of the low PSA. I had to insist. Turns out I had a Gleason 4+4 prostate cancer that just did not produce PSA. I had a RP, then a recurrence several years later, 37 radiation treatments, 5 months of Orgovyx, and my PSA has been undetectable for the last two years. I am a big advocate of the DRE as well as the PSA. Many doctors don't do it, some of the literature discourages it, but for the 10% or so who have prostate cancer that does not produce PSA, it can be a life saver. It probably was for me.

It will be three years in September since I was diagnosed. My PCP had me go in for biopsy because my PSA was bouncing up and down for a couple of years. Needless to say what a shock. The last PSA before diagnosis was 8.
Later I was classed Gleason 4+3/7 intermediate.
I ended up having hi beam Proton radiation with 3 shots of ADT. Needless to say, I am having issues with the side effects from the hormone shots.
But at my last checkup, my surgeon informed me that I had the lowest PSA number ever of all the patients in the practice.