I'd also like to bring in some other members who may be interested in this discussion on ketamine nasal spray and its availability: @mommjonie6 @parus @gailb @etranger @godsgirl1969 @jimhd @georgette12 @charlie75 @desirea @kdo0827 @windwalker @ainsleigh. Hoping that @overwhelmed @amberpep @deadpoets will also return to this conversation and offer their insights.

I took 1 ketamine infusion 2 weeks ago for severe depression and now my brain fog is worse and I have disassociation feelings where I feel like I am in in a dream state. I really regret taking it. They gave me 1 mg/kg for a total of 60 over 1 hr. I heard .5 was a better doseage. Does anyone know of any medications I can take to deal with these symptoms? I am worried I did long term damage to my brain. My brain fog is the worst in the morning and it gets a little better by midday but it is always there. I also take Seroquel at night. Is it a combination of the Seroquel and Ketamine?. I am desperate to feel better.

Hi, @czechmate – you'll note I moved your post to this discussion, "Ketamine treatments," so that you could talk with others who have discussed this therapy. That is tough to feel like you have brain fog and disassociation feelings, and feel regret for undergoing the therapy.

I'd like to invite other members who have talked about ketamine in this discussion or elsewhere on Connect to join in and offer any thoughts on the feelings you are having post-treatment and how you might manage the symptoms. Please meet @hopeful123 @overwhelmed @mary121658 @racheldmark @jdrhoads. @gailb and @jakedduck1 may also have some input.

@czechmate – did your doctor offer any thoughts on what side effects you might experience, and how you might deal with them if they occurred?

Hi @czechmate, it is possible that the combination of Seroquel and Ketamine are making it worse. Have you talked with your doctor or pharmacist about the symptoms and possible side effects?

Drug interactions between ketamine and Seroquel
— https://www.drugs.com/drug-interactions/ketamine-with-seroquel-1411-0-1979-1274.html

I took 1 ketamine infusion 2 weeks ago for severe depression and now my brain fog is worse and I have disassociation feelings where I feel like I am in in a dream state. I really regret taking it. They gave me 1 mg/kg for a total of 60 over 1 hr. I heard .5 was a better doseage. Does anyone know of any medications I can take to deal with these symptoms? I am worried I did long term damage to my brain. My brain fog is the worst in the morning and it gets a little better by midday but it is always there. I also take Seroquel at night. Is it a combination of the Seroquel and Ketamine?. I am desperate to feel better.

Hi, @czechmate – I wanted to let you know I moved your post on ketamine side effects here, as members have talked about this treatment in this discussion. @merpreb @johnbishop @jenniferhunter may have some thoughts on the brain fog and disassociation feelings you've had since your ketamine infusion 2 weeks ago and your concern about long-term damage to your brain.

Hi @czechmate — I have no experience with ketamine infusions but have read that there are some significant side effects. Here is some information I found that tells about the side effects.

Ketamine for chronic pain: risks and benefits
— https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014022/

Have you discussed your new symptoms with your doctor?

@czechmate– I'm so sorry that you feel worse. During my chemo years ago I did have chemo brain. Since I am not familiar with Ketamine I don't know if this would cause the same thing. I'm wondering if all the drugs that you are taking are reacting with each other in a negative way. Perhaps the Ketamine set a reaction off.
Like John, I can only offer you this link
https://www.webmd.com/depression/features/what-does-ketamine-do-your-brain#1
Please continue to bug your doctors about this.

@dpstewart318

FDA Approves Ketamine-Related Drug for Depression

The Food and Drug Administration approved a drug for depression that could be the first in a wave of long-awaited treatments, but that has also raised concerns about abuse.

Hi, @mikecranny – Thanks for sharing information on the FDA approval of esketamine, a nasal spray that's a relative of ketamine, for treatment-resistant depression.

This article talks about this development https://www.npr.org/sections/health-shots/2019/03/05/700509903/fda-clears-esketamine-nasal-spray-for-hard-to-treat-depression

Have you had experience with depression, @mikecranny? Is this a medication you are potentially interested in for yourself?

What are your thoughts about FDA approval of esketamine, @dstewart318?

Yes, I've had anxiety and depression and thankfully it's under control. I thought it would be of general interest.