JAK2 Mutation - Effects and Questions

I assume that all if us who have blood cancers have immune deficiencies so traveling to any area that has active outbreaks of the coronavirus isn't a good idea. As I understand it, older people with underlying health issues are the people who are most likely to succumb to the coronavirus or the Type B flu if not inoculated. Of course traveling on a plane places you in close quarters with other passengers and increases the likelihood if exposure to all kinds of nasty things. We're scheduled to go to Northern Italy in late June. Not sure if that trip will be canceled but it doesn't look good at the moment.

Look online for facts about high platelets (ET). The doctors use this general rule of thumb: patients under 60 (& "low risk," meaning not other problems or malfunctions), take 1 aspirin. Over 60 (& if scores are high consistently, & esp. if you have other issues) need more meds. I take 500 mg Hydroxyurea daily (was 5 days for first 2 years), exercise, sleep more than I used to!), eat well, and focus on wellness. I am 67 and get more tired but that's probably age too:-) Not sure now if I should travel this April with coronavirus and a stop in London & JFK airports....but there are cases here on West Coast too....

I am in agreement.

Just because you have the JAK2 mutation it doesn't mean you cannot have other gene mutations. I suggest you get the none marrow aspiration, biopsy and molecular panel done. Knowledge is power. Once you're properly diagnosed your oncologist will know how to treat you.

I'm five mos in from the discovery of JAK 2, started at 680, now hovering above 1 mill platelet count. Haven't tested marrow, scan shows spleen is normal. Remainder of blood test is within range, just starting 500 mg hydroxyurea and 300 mg allopurinol daily. My Hematologist doesn't think this will progress into other diseases, should pretty much be a situation of lowering platelet count and monitoring it.

Hi, I haven't been diagnosed with PV yet, but I'm getting the JAK2 test done soon. All of my blood counts are elevated and have been for some time. My sister, aunt, cousin, and second cousin all have Crohn's disease. Some of the research I've done has linked Crohn's with the JAK2 gene. Does anyone have info on the JAK2 and Crohn's? Does anyone else have family members with Crohn's that are suffering from PV?

Are you on any meds? Hydroxyurea is usually prescribed to reduce a high platelet count. You should get a bone marrow procedure and a molecular panel to identify what’s really going on and which genes have mutated. Good luck.

With my ET; my latest B12 reading is over 2,000, twice the upper limit. Is this indicative of anything? And my platelet count exceeds 1 mill, we will be discussing meds to lower it.

So how was your ET, JAK2 Positive diagnosed? Did your Hematologist or Oncologist do a bone marrow procedure and molecular panel? Sometimes doctors use a blood smear which only looks at the most common gene mutations. The molecular panel looks at 400 genes. You need to know what genes gave mutated so your doctor can properly treat you. Good luck.

Im given aspirin and posibly jak2 might b repeated , do these MPNs progress with time like is it a norm for them to progress or can it stay in the same ratios ? Is ET blood cancer ? Im young 31 so can it go into remission on its own or naturaly if i keep good diet ? Also does black seed cause any affect to cell proliferation ive read on certain pages that its effective natural med ? Any views.... i might have jak2 neg ET because all readings r normal just platelets are high and im asymptomatic . Is jak2 pos ET more dangerous than jak2 negative???