I have MDS/MPN Overlap. On the MPN side I have ET and MF. I recently developed a heart problem and had an ablation at the Stony Brook University Heart Institute. I was having 22,000 PVCs which is extra beats along with super ventricular episodes. Based on my blood cancer history the doctors at Stony Brook opted to skip trying drugs and go straight to the ablation procedure. I'm better now, no more PVCs. My question is – does anyone have a heart issue after testing positive for the JAK2 gene mutation? A Hematologist at the VA Hospital in Northport told me there is scientific evidence linking the JAK2 mutation and heart disease. Something referred to as "CHIP".