Is my statin causing peripheral neuropathy?

Posted by natejr @natejr, Dec 22, 2023

In June 2023, my physician prescribed Rosuvastatin Calcium 40 MG to lower my LDL below 70. In September 2023, I started to experience numbness and tingling in my fingertips so I was referred to a neurologist who ordered an EMG for carpal tunnel. The test results indicated that there was no Electrodiagnostic evidence of neuropathy in either upper extremity or of right cervical radiculopathy.
Based on that diagnosis, I was left with the conclusion that I did not have neuropathy and started to pursue other reasons this could be happening.

In the meantime, I noticed that when I took Doxepin 10 MG; a medication I had been prescribed for insomnia, the pain when away. So, I started taking 1 capsule of Doxepin each night and the pain subsided for the entire day so I continued taking them on a daily basis. Over time, the numbness and tingling in my fingertips stopped and that’s when I started experiencing what felt like I was being stabbed all over my body throughout the day. At this point, I was taking 1 Doxepin capsule twice a day and it helped manage the nerve pain.

In November 2023, I received the lipid panel results of being on Rosuvastatin. My LDL was reduced from 78 to 55.6; which achieved the desired results. On a positive note, my HbA1C remained at 5.4 but my Creatine Kinase increased to 300 (Normal Range: 60 – 270). Also, for the first time, I had protein in my urine with a value of 30 mg/dl; which is the highest level of normal. At this point, I stopped taking Rosuvastatin and started taking Atorvastatin Calcium 80 MG. In addition to this, I started taking Gabapentin 300 MG; one capsule three times a day. I have an appointment to see a neurologist to hopefully diagnosis what’s happening with me but that’s not until May 2024. In an attempt to better understand neuropathy and taking a statin I learned that the National Institutes of Health indicated that neuropathy was observed in a neurological examination performed within the first year in 50% of the Rosuvastatin users and 18% of those taking Atorvastatin. The severity of the polyneuropathy increased with the duration of the treatment in the Atorvastatin group (p=0.030).

Meanwhile, I continue taking the Gabapentin every eight hours but there are times when the pain is almost unbearable. My current schedule is: 7am – 3pm, 3pm – 11pm, and 11pm – 7am. The time frame that’s the most difficult for pain is 3pm – 11pm and for whatever reason, the medication’s effectiveness during this time frame only provides relief for and average of four hours versus eight hours during the other two periods.

Has anyone had any experience taking either of these statins and have been diagnosed with neuropathy? If so, are you aware of a statin that effectively lowers your LDL without causing neuropathy?

Interested in more discussions like this? Go to the Neuropathy Support Group.

@janieel

Do you gave a high HDL (good cholesterol)? Your total cholesterol number will be high if you have a high good cholesterol. I’m sure you must be aware that it’s the LDL (bad cholesterol) that you should try to keep at 100 or below. Mine had creeped up to 139 which is why my doctor switched my statin to a stronger one, and which is what I think caused my neuropathy slowly over the last 5 months after the switch. My HDL has always been high, but that’s the good cholesterol. It’s always over 100. Normal is over 40.
Yes, I also have high cholesterol because of family. My father’s cholesterol was crazy, crazy high. While I'm on no cholesterol medication at the tine, I’m trying to eat healthy too. I don’t use butter anyway, so that’s not a problem. I use olive oil or olive oil cooking spray. Fruits, veggies, whole grains, poultry and very little red meat. Unfortunately, I don’t like fish which I know is good for me. I also read that salt isn’t good for neuropathy, so I cut out chips and other salty foods, including cold cuts which are high in nitrates and also bad.

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https://www.foundationforpn.org/causes/other-drugs/
This is the list of stations that cause neuropathy on the Foundation Of Peripherial Neuropathy web page.

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@janieel

Did you quit statins because of neuropathy? Glad that you found another way to fight cholesterol! I’ll, Jeep this drug in mind for the future.

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Yes. Statins may have been the cause of my neuropathy but we don't know for sure. The Repatha is better at controlling my lipids

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I too took rosuvostatin, then autorvastatin for years. Several years after being diagnosed with non-diabetic idiopathic PN I read about statins potentially causing PN, went to my GP and he switched me to a non-statin Ezetimbe that seems to be handling the LDL effectively. The change had little or no impact on my PN but at least I have eliminated one potential PN cause.

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I had an aortic valve replaced in July, 2015 and was prescribed Atorvastatin to maintain my LDL level in normal range, although my LDL levels have never been high. I would occasionally have cramping in my calves and feet, but never paid much attention, as the cramps were not happening on a regular basis. Fast forward to April 2023...I had two stents inserted into one artery, because there was some blockage in the anterior artery of the heart. I've continued taking the Atorvastatin, but the the cramps in calves and feet began to occur nightly and I was getting up 3-4 times nightly to stretch and massage the calves and feet. After seeing my doctor to get her input as to what may be causing the symptoms, which had become severe at times, my doctor informed me that one of the side effects of Atorvastatin is muscle cramps! So she prescribed Rosuvastatin and it did not help, as the nightly cramps continued. I had a series of test to see if it may be related to circulation in lower extremities. There was no blockage in either leg. Since then, I have decided on my own to discontinue the statin drugs. My PCP prescribed Gabbapentin as a last resort. I been taking a low dose of Gabbapentin (100mg) at bedtime, increased my dosage of melatonin to 5mg, and taking a magnesium supplement at bedtime. I am seeing positive results, as the cramping in both calves and feet have been minimal or manageable for the last few nights. I still have a little numbness in the calves, but at least not having to get up during the night to stretch and walk around in the middle of the night. My PCP still has still not diagnosed my condition, but only through this website and blog have I determined that what I'm experiencing is PN.

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@janieel

Thank you!
I have an appointment next week with a neurologist after my testing all coming out showing nothing that would cause neuropathy (bloodwork, cervical MRI, Nerve conduction study/EMG). I did share my concerns with a nurse practitioner neighbor and she told me it would take as long a time that I was taking Rosuvastatin for the symptoms to diminish (I took rosuvastatin fir 6 months, so it’ll take 6 months + fir the symptoms to diminish. Hoping she’s right.

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Hi…you probably know this…but the sensations you are having ( if it’s truly neuropathy) would likely be small fiber neuropathy…tingling, numbness etc. This type is not able to be detected on a nerve conduction study. Small fiber neuropathy is diagnosed via a skin puncture biopsy typically. FYI

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@stallen

Hi…you probably know this…but the sensations you are having ( if it’s truly neuropathy) would likely be small fiber neuropathy…tingling, numbness etc. This type is not able to be detected on a nerve conduction study. Small fiber neuropathy is diagnosed via a skin puncture biopsy typically. FYI

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Thanks for the info. Let’s see what my neurologist says on Tuesd. Maybe he’ll suggest the skin biopsies.

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@janieel

So I take it red yeast rice could also have the same side effects, neuropathy? Or, are you saying to us instead of a statin?

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I take red yeast rice after stopping statin. It is working without worsening neuropathy.

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@marymaurer

I take red yeast rice after stopping statin. It is working without worsening neuropathy.

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I am taking leqvio. Start one shot, second one three months later and then every six months. Paid for 100% by the manufacturers patient advocacy program.

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@vbadeaux

I had an aortic valve replaced in July, 2015 and was prescribed Atorvastatin to maintain my LDL level in normal range, although my LDL levels have never been high. I would occasionally have cramping in my calves and feet, but never paid much attention, as the cramps were not happening on a regular basis. Fast forward to April 2023...I had two stents inserted into one artery, because there was some blockage in the anterior artery of the heart. I've continued taking the Atorvastatin, but the the cramps in calves and feet began to occur nightly and I was getting up 3-4 times nightly to stretch and massage the calves and feet. After seeing my doctor to get her input as to what may be causing the symptoms, which had become severe at times, my doctor informed me that one of the side effects of Atorvastatin is muscle cramps! So she prescribed Rosuvastatin and it did not help, as the nightly cramps continued. I had a series of test to see if it may be related to circulation in lower extremities. There was no blockage in either leg. Since then, I have decided on my own to discontinue the statin drugs. My PCP prescribed Gabbapentin as a last resort. I been taking a low dose of Gabbapentin (100mg) at bedtime, increased my dosage of melatonin to 5mg, and taking a magnesium supplement at bedtime. I am seeing positive results, as the cramping in both calves and feet have been minimal or manageable for the last few nights. I still have a little numbness in the calves, but at least not having to get up during the night to stretch and walk around in the middle of the night. My PCP still has still not diagnosed my condition, but only through this website and blog have I determined that what I'm experiencing is PN.

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I'm concerned that you discontinued the statin without replacing it with a non-statin medication for high cholesterol. The concern is that your arteries could clog again. Do you have an appointment with your PCP to request a different medication to lower cholesterol?

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