Is it small intestinal fungal overgrowth (SIFO)?

Posted by jlstjohn @jlstjohn, Dec 15, 2024

I just finished a course of ciprofloxacin plus metronidazole to empirically treat SIBO. Not my first rodeo with it, been treated at least half a dozen times. We are to the point where we do not do breath tests anymore, just go off of symptoms as I am very prone to it (SBS, no ileocecal valve, slow transit/history of constipation). I take Xifaxan 500 mg twice daily to prevent, but this is the 2nd time I have had a "flare" that has required different antibiotic treatment. I quit the ciprofloxacin halfway through due to side effects. I felt great improvement the 1st week after completing the course, but now symptoms are returning (bloating, gas, diarrhea, fullness right after a meal, fatigue). Has anyone gone through treatment for SIFO, either while getting treatment for SIBO or just on its own? I am highly suspicious and would like to hear success stories and/or tips.

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My GI doctor also does not address SIFO. I have done curcumerin 300 to 500 mg orally twice daily for 4 weeks as outlined in Dr. William Davis' book Super Gut. Because you want the supplement to stay in the intestinal tract and NOT get absorbed, he recommends only certain brands for this purpose: NOW curcumerin softgels, Jarrow Formula curcumin 95, Life Extension curcumin Elite rxtracr, and Solaray curcumin. He also has other ideas in the book. I have seen some improvement when I have implemented his strategies, but I certainly do not agree with everything he says.

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Thank you! I just finished reading the book Super Gut so know exactly what you are referring to. It’s a journey of trial and error for me. I appreciate your response!

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