Anyone else experiencing increased migraine while on Exemestane?

no thank goodness , but lot of joint pain , now the kneees are bad after 6 months on it

I have been on Anastrozole for 6 years now after breast cancer and suffer from migraines every 7 days. I’m post menopausal so I feel its definitely related to the Anastrozole. Ive searched the internet to find if this has occurred with others but this is the first post Ive come across. I think i may have to go back to oncologist and see what alternatives I can try although I feel all these drugs work in the same way.

@janert8 yes that’s what my oncologist said they all work the same way. My neurologist said anytime you deal with hormones you are in danger of migraines if you are prone. I wish I had an answer . I am surprised more of us have not brought this up. Good luck -keep in touch

thanks for reply! I’m pretty sure there are more people out there who have also experienced this but I’m guessing they just get on with it. I know Anastrozole is not the cause of migraines as I’ve had them a long time before starting on it, but they are without a doubt triggering something to set them off on a regular basis. Its a no win situation because I have to keep taking them for another four years, stopping isn’t an option.
Yes keep in touch and if you find anything that helps you know where to find me! 😊

I don't understand why oncologists said "it’s not the drug!"? It is on drug manual and popped up on google search.

I don’t understand it either. It seems to me common sense that anything that affects hormones would affect migraines. But I was told the same thing by both my oncologist- who is a very well respected breast cancer doctor- and my neurologist who is a headache specialist. Both of them shook their heads when I mentioned the Exemestane causing migraines. The only person who seem to see a real connection was the second neurologist I went to last week. But, I have brought this topic up in other support group forums and had very little response. So either it’s not so common or other people are just taking their doctors word for it not being related. It seems pretty simple to me, unfortunately they are drugs we can’t seem to do without.

I suffered a concussion in 2019 from a fall and still paying the price for it. This kick started chronic migraines for me.
My neurologist said I had "refractory" migraines which means nothing seems to help with the pain.
I also have heart disease and can not take the triptans - which are the first line of defense in treatment and "usually" effective. I must stay with the CGRPs which, I found, do nothing for me. My ice pack is more helpful...
I have been on Anastrozole for only 4 months now. Constant daily headache but a bit different than a migraine. This kind of headache is a feeling of complete pressure in my head as if it is going to explode...beyond annoying.
My migraines are always on the right side temple, throbbing and also some brain spasms like shock waves, if they lasted longer than just seconds it would be a 911 call. They are so painful.
My new breast cancer oncologist is now putting me on Letrozole. Will this help with my headaches?
Who knows?
Seeing my neurologist this week. It will be interesting (after reading the posts here) to see what he says about the headaches that started after taking the AI and his take on if related.
Yes, we are in a no win situation, a rock and a hard place. The AIs can cause a heart attack or a stroke in women who already have ischemic heart disease (me). I have basically 5 more years to go. I don't know if I will make it.
Best wishes to all.

O know the freling I fell backwards onto a hardwood floor was almost knocked out. I have seen two neuro surgeons 2 ortho surgeons they all say I am fine. But have migrains and left hand throns in thumb snd pointer finger into the backside of arm up onto neck. Mow I have a numb shoulder up into my head with the head scalp itching. Left
Leg os numb in groin and saddle area. Had nerve conduction test snd said all nerves are ok. Anyone ever experience all this with a concussion?

I'm taking exemestane now, and started AIs about a year ago. My only side effect (if it is one) is mild trigger finger on the middle finger of my right hand. So far, no headaches or migraines, although I had ocular migraines (which are painless) every few days for a couple of weeks, maybe 2 months ago. I've had ocular migraines before, but not with such frequency. They seemed to have gone away--not sure what caused them--neither was the doctor.